MOUSE ANTI HUMAN LYSOZYME | MyBioSource MBS211340 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI HUMAN LYSOZYME

catalog :

MBS211340

quantity :

0.2 mg

price :

390 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

BGN/0696/5B1

reactivity :

human

application :

ELISA, flow cytometry, FACS, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS211340

products type :

Antibody

products full name :

MOUSE ANTI HUMAN LYSOZYME

products short name :

LYSOZYME

other names :

lysozyme C; Lysozyme C; lysozyme C; 1,4-beta-N-acetylmuramidase C; c-type lysozyme; lysozyme; 1,4-beta-N-acetylmuramidase C

other gene names :

LYZ; LYZ; LZM; LZM

uniprot entry name :

LYSC_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

BGN/0696/5B1

host :

Mouse

sequence length :

148

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

ELISA (EIA), Flow cytometry (FC/FACS)*, Immunohistology Paraffin*

app notes :

Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Flow Cytometry: Maximum Dilution: 1/10; Application Note: Membrane permeabilization is required for this application. MyBioSource recommends the use of Leucoperm for this purpose. . Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein A

other info2 :

Histology Positive Control Tissue: Human Tonsil. Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

Mouse anti Human Lysozyme antibody, clone BGN/0696/5B1 recognizes lysozyme, an enzyme that is present in mucosal secretions such as saliva and tears and is involved with non-specific organism defence. It functions by hydrolyzing 1,2-beta linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues such as those found in the walls of various Gram-positive bacteria.

ncbi gi num :

4557894

ncbi acc num :

NP_000230.1

ncbi gb acc num :

NM_000239.2

uniprot acc num :

P61626

ncbi mol weight :

16,537 Da

ncbi pathways :

Amyloids Pathway (366238); C-MYB Transcription Factor Network Pathway (138073); Disease Pathway (530764); Salivary Secretion Pathway (153376); Salivary Secretion Pathway (153352)

ncbi summary :

This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]

uniprot summary :

LYZ: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents. Defects in LYZ are a cause of amyloidosis type 8 (AMYL8); also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. Belongs to the glycosyl hydrolase 22 family. Protein type: Endoplasmic reticulum; EC 3.2.1.17; Secreted, signal peptide; Secreted; Hydrolase; Vesicle. Chromosomal Location of Human Ortholog: 12q15. Cellular Component: extracellular space; extracellular region. Molecular Function: identical protein binding; lysozyme activity. Biological Process: retinal homeostasis; metabolic process; cytolysis; defense response to bacterium; inflammatory response. Disease: Amyloidosis, Familial Visceral

size1 :

0.2 mg

price1 :

390 USD

more info or order :

MyBioSource product webpage