This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
RAT ANTI MOUSE DECTIN-2:Low Endotoxin
catalog :
MBS211248
quantity :
0.5 mg
price :
515 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
D2.11E4
reactivity :
mouse
application :
immunoprecipitation, flow cytometry, FACS
product information
catalog number :
MBS211248
products type :
Antibody
products full name :
RAT ANTI MOUSE DECTIN-2:Low Endotoxin
products short name :
DECTIN-2
other names :
C-type lectin domain family 6 member A isoform 3; C-type lectin domain family 6 member A; C-type lectin domain family 6 member A; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 10; C-type lectin superfamily member 10; DC-associated C-type lectin 2; dectin-2; dendritic cell-associated C-type lectin 2; natural killer complex lectin; C-type lectin domain family 4, member n; C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2; DC-associated C-type lectin 2; Dectin-2
products gene name :
DECTIN-2
other gene names :
Clec4n; Clec6a; Nkcl; Clec6a; Clecsf10; Clec4n; Clecsf10; Dectin2; DC-associated C-type lectin 2; Dectin-2
uniprot entry name :
CLC6A_MOUSE
clonality :
Monoclonal
isotype :
IgG2a
clone :
D2.11E4
host :
Rat
sequence length :
168
form :
Low Endotoxin. Purified IgG - liquid
concentration :
IgG concentration 1.0 mg/ml
storage stability :
Store at -20 degree C only. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Immunohistology Frozen, Flow cytometry (FC/FACS), Immunoprecipitation (IP)
app notes :
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Flow Cytometry: Minimum Dilution: 1/10; Maximum Dilution: 1/100
other info1 :
Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
other info2 :
Immunogen: Dectin-2 (extracellular domain) Fc Fusion protein. Buffer Solution: Phosphate buffered saline. Target Species: Mouse
products description :
Rat anti Mouse Dectin-2 antibody, clone D2.11E4 recognizes mouse DC-associated C-type lectin-2 (Dectin-2), a type II transmembrane protein that is a member of the C-type lectin superfamily. In mouse, dectin-2 is predominantly expressed on tissue macrophages and some dendritic cells. Clone D2.11E4 does not stain brain microglia or meningeal macrophages. Significant expression of Dectin-2 has been reported on macrophages in the red pulp and marginal zones of the spleen, kupffer cells in the liver and alveolar macrophages in the lung. Peripheral blood monocytes express low levels of dectin-2 but transient up-regulation of expression has been demonstrated on monocytes at sites of inflammation. The function of dectin-2 has not been fully determined but studies suggest a possible role in immune-surveillance.
ncbi gi num :
298358452
ncbi acc num :
NP_001177250.1
ncbi gb acc num :
NM_001190321.1
uniprot acc num :
Q9JKF4
ncbi mol weight :
19,332 Da
uniprot summary :
dectin-2: Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Cellular Component: membrane; integral to membrane. Molecular Function: protein binding; carbohydrate binding. Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; immune system process; innate immune response; defense response to fungus; positive regulation of cytokine secretion
size1 :
0.5 mg
price1 :
515 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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