This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
MOUSE ANTI HUMAN CD221:Low Endotoxin
catalog :
MBS211237
quantity :
0.5 mg
price :
550 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1H7
reactivity :
human
application :
western blot, flow cytometry, FACS
product information
catalog number :
MBS211237
products type :
Antibody
products full name :
MOUSE ANTI HUMAN CD221:Low Endotoxin
products short name :
CD221
other names :
insulin-like growth factor 1 receptor isoform 1; Insulin-like growth factor 1 receptor; insulin-like growth factor 1 receptor; IGF-I receptor; insulin-like growth factor I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD_antigen: CD221Cleaved into the following 2 chains:Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain
products gene name :
CD221
other gene names :
IGF1R; IGF1R; IGFR; CD221; IGFIR; JTK13; IGF-I receptor
uniprot entry name :
IGF1R_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
1H7
host :
Mouse
sequence length :
1,367
form :
Low Endotoxin. Purified IgG - liquid
concentration :
IgG concentration 1.0 mg/ml
storage stability :
Store at -20 degree C only. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Flow cytometry (FC/FACS), Functional Assays (FN), Immunohistology Paraffin*, Western Blot (WB)
app notes :
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Flow Cytometry: Maximum Dilution: 1/10. Immunohistology - Paraffin: Minimum Dilution: 1/10; Maximum Dilution: 1/40; Application Note: This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase.
other info1 :
Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
other info2 :
Histology Positive Control Tissue: Pancreas, placenta. Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the SP2/0 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Human
products description :
Mouse anti Human CD221 antibody, clone 1H7 recognizes human CD221, a 155kD receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. Clone 1H7 recognizes an epitope in the alpha subunits of CD221, demonstrated by Western blotting (Li et al.1993). CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin. The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins. Clone 1H7 is reported to partically block binding of IGF-I and IGF-II to CD221 (Li et al.1993).
ncbi gi num :
4557665
ncbi acc num :
NP_000866.1
ncbi gb acc num :
NM_000875.4
uniprot acc num :
P08069
ncbi mol weight :
154,793 Da
ncbi pathways :
AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!Apoptosis Pathway 198797!!Endochondral Ossification Pathway 198812!!Endocytosis Pathway 102279!!Endocytosis Pathway 102181!!Focal Adhesion Pathway 198795!!Focal Adhesion Pathway 83067
ncbi summary :
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
size :
0.5 mg
price :
550 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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