catalog number :
MBS211229
products full name :
HAMSTER ANTI MOUSE CD61:Low Endotoxin
products short name :
CD61
other names :
integrin beta-3; Integrin beta-3; integrin beta-3; GPIIIa; platelet gpIIIa; platelet membrane glycoprotein IIIa; integrin beta 3; Platelet membrane glycoprotein IIIa; GPIIIa; CD_antigen: CD61
products gene name :
CD61
other gene names :
Itgb3; Itgb3; CD61; GP3A; INGRB3; GPIIIa
uniprot entry name :
ITB3_MOUSE
form :
Low Endotoxin. Purified IgG - liquid
concentration :
IgG concentration 1.0 mg/ml
storage stability :
Store at -20 degree C only. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Shelf Life: 18 months from date of despatch.
tested application :
Flow cytometry (FC/FACS), Functional Assays (FN), Immunoprecipitation (IP)
app notes :
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Flow Cytometry: Minimum Dilution: 1/25; Maximum Dilution: 1/50
other info1 :
Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
other info2 :
Immunogen: Mouse alpha 5 beta 3 protein purified from the mouse hybridoma 2B4. Fusion Partners: Spleen cells from immunised Armenian hamsters were fused with cells of the P3U1 mouse myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Mouse
products description :
Hamster anti Mouse CD61 antibody, clone HM beta 3-1 recognizes the murine integrin beta 3 subunit (CD61), a 90kDa a type I membrane protein, which is expressed primarily on megakaryocytes, platelets, monocytes, macrophages, granulocytes and endothelial cells. CD61 associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) to form the platelet glycoprotein complex IIb/IIIa and the vitronectin receptor (VNR) respectively. The heterodimers formed with CD61 are receptor for a variety of ligands including fibrinogen, fibronectin, von Willebrands factor (vWF), vitronectin and thrombospondin. Hamster anti Mouse CD61 antibody, clone HM beta 3-1 is reported to partially inhibit the binding of CD61 to fibronectin (Yasuda et al. 1995).
ncbi acc num :
NP_058060.2
ncbi gb acc num :
NM_016780.2
ncbi mol weight :
86,738 Da
ncbi pathways :
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 117303!!Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 116129!!Axon Guidance Pathway 1111058!!Developmental Biology Pathway 1111057!!Dilated Cardiomyopathy Pathway 121495!!Dilated Cardiomyopathy Pathway 121285!!ECM Proteoglycans Pathway 1110314!!ECM-receptor Interaction Pathway 83265!!ECM-receptor Interaction Pathway 479!!Elastic Fibre Formation Pathway 1110309