MOUSE ANTI HUMAN CD81:Low Endotoxin | MyBioSource MBS211208 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI HUMAN CD81:Low Endotoxin

catalog :

MBS211208

quantity :

0.5 mg

price :

550 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1D6

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation, flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS211208

products type :

Antibody

products full name :

MOUSE ANTI HUMAN CD81:Low Endotoxin

products short name :

CD81

other names :

CD81 antigen isoform 2; CD81 antigen; CD81 antigen; 26 kDa cell surface protein TAPA-1; CD81 antigen (target of antiproliferative antibody 1); tetraspanin-28; tspan-28; CD81 molecule; 26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28; CD_antigen: CD81

products gene name :

CD81

other gene names :

CD81; CD81; S5.7; CVID6; TAPA1; TSPAN28; TAPA1; TSPAN28; Tspan-28

uniprot entry name :

CD81_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

1D6

host :

Mouse

sequence length :

236

form :

Low Endotoxin. Purified IgG - liquid

concentration :

IgG concentration 1.0 mg/ml

storage stability :

Store at -20 degree C only. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Flow cytometry (FC/FACS), Functional Assays (FN), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistology Paraffin, Western Blot (WB)

app notes :

Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Flow Cytometry: Maximum Dilution: 1/10

other info1 :

Preparation: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant

other info2 :

Immunogen: OCI-LY8 cells aggregated by 5A6 (another CD81 antibody). Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the mouse PX3-Ag.8.653 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

Mouse anti Human CD81 antibody, clone 1D6 recognizes human CD81, a 26kDa cell surface antigen also known as TAPA-1, and a member of the tetraspanin family. CD81 is widely expressed on human leucocytes and appears to be involved in a variety of cellular leucocytes including activation, proliferation and differentiation. Mouse anti Human CD81 antibody, clone 1D6 is a potent CD81 reagent, induces homotypic adhesion and has powerful anti-proliferative effects.

ncbi gi num :

663071018

ncbi acc num :

NP_001284578.1

ncbi gb acc num :

NM_001297649.1

uniprot acc num :

P60033

ncbi mol weight :

25,809 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); Hepatitis C Pathway (173973); Hepatitis C Pathway (173907); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413); Malaria Pathway (152665); Malaria Pathway (152657)

ncbi summary :

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

uniprot summary :

CD81: May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV. Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6); also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the tetraspanin (TM4SF) family. Protein type: Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: focal adhesion; membrane; integral to plasma membrane; plasma membrane; immunological synapse; vesicle. Molecular Function: protein binding. Biological Process: cell proliferation; virion attachment, binding of host cell surface receptor; entry of virus into host cell; regulation of immune response; positive regulation of peptidyl-tyrosine phosphorylation; protein localization; activation of MAPK activity; positive regulation of cell proliferation; positive regulation of 1-phosphatidylinositol 4-kinase activity; phosphatidylinositol biosynthetic process; positive regulation of B cell proliferation; phosphatidylinositol metabolic process. Disease: Immunodeficiency, Common Variable, 6

size1 :

0.5 mg

price1 :

550 USD

more info or order :

MyBioSource product webpage