RAT ANTI MOUSE CD16/CD32:FITC | MyBioSource MBS210943 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RAT ANTI MOUSE CD16/CD32:FITC

catalog :

MBS210943

quantity :

0.1 mg

price :

205 USD

clonality :

monoclonal

host :

rat

conjugate :

FITC

clone name :

FCR4G8

reactivity :

mouse

application :

flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS210943

products type :

Antibody

products full name :

RAT ANTI MOUSE CD16/CD32:FITC

products short name :

CD16/CD32

other names :

low affinity immunoglobulin gamma Fc region receptor II-b isoform 2; Low affinity immunoglobulin gamma Fc region receptor II; low affinity immunoglobulin gamma Fc region receptor II-b; Fc gamma RIIB; Fc-gamma-RII; FcgammaRIIB; fc gamma receptor IIB; fc-gamma RII; fc-gamma-RIIB; igG Fc receptor II beta; lymphocyte antigen 17; Fc receptor, IgG, low affinity IIb; Fc gamma receptor IIB; Fc-gamma RII; Fc-gamma-RIIB; FcRII; IgG Fc receptor II beta; Lymphocyte antigen 17; Ly-17; CD_antigen: CD32

products gene name :

CD16/CD32

other gene names :

Fcgr2b; Fcgr2; CD32; Fcgr2; Fcr-2; Fcr-3; Ly-17; LyM-1; Lym-1; fcRII; FcgRII; Fcgr2a; Ly-m20; AI528646; Fc[g]RII; F630109E10Rik; Fcgr2b; Ly-17; Fc-gamma RII; Fc-gamma-RIIB; FcRII; Ly-17

uniprot entry name :

FCGR2_MOUSE

clonality :

Monoclonal

isotype :

IgG2b

clone :

FCR4G8

host :

Rat

sequence length :

293

form :

FITC. Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid

concentration :

IgG concentration 0.1 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Flow cytometry (FC/FACS)

app notes :

Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Flow Cytometry: Minimum Dilution: Neat; Maximum Dilution: 1/10

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide. 1% Bovine Serum Albumin. Preparation: Purified IgG prepared by affinity chromatography on Protein G

other info2 :

Immunogen: PU5 1.8 IOE7 Balb/c mouse cell line. Fusion Partners: Cells from immunised rats were fused with cells of the mouse P3X63-Ag8.653 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Mouse

products description :

Rat anti Mouse CD16/CD32 antibody, clone FCR4G8 recognizes an epitope expressed by the murine low affinity Fc receptors, Fc gamma III (CD16) and Fc gamma II (CD32). In the mouse only the transmembrane form of CD16 is reported to exist, which is expressed on macrophages, NK cells, granulocytes, myeloid precursors, and subpopulations of T lymphocytes. CD32 is primarily expressed on cells of the myeloid lineage and also on mature B lymphocytes.

ncbi gi num :

6857783

ncbi acc num :

NP_034317.1

ncbi gb acc num :

NM_010187.2

ncbi mol weight :

ncbi pathways :

B Cell Receptor Signaling Pathway (198285); B Cell Receptor Signaling Pathway (83278); B Cell Receptor Signaling Pathway (492); FCGR Activation Pathway (1110768); Fc Gamma R-mediated Phagocytosis Pathway (114297); Fc Gamma R-mediated Phagocytosis Pathway (106590); Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway (1110767); Immune System Pathway (1110668); Innate Immune System Pathway (1110697); Measles Pathway (213308)

uniprot summary :

FCGR2B: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed. Protein type: Membrane protein, integral; Oncoprotein; Cell surface. Cellular Component: recycling endosome; cell surface; cytoskeleton; membrane; integral to plasma membrane; cytoplasm; plasma membrane; extracellular region; integral to membrane; lipid raft; external side of plasma membrane. Molecular Function: protein binding; IgG binding; receptor signaling protein activity; immunoglobulin binding. Biological Process: receptor-mediated endocytosis; negative regulation of phagocytosis; negative regulation of interleukin-10 production; negative regulation of acute inflammatory response to antigenic stimulus; negative regulation of immune response; antigen processing and presentation of exogenous peptide antigen via MHC class II; defense response; negative regulation of B cell proliferation; endocytic recycling; negative regulation of type I hypersensitivity; mast cell activation; negative regulation of neutrophil apoptosis; negative regulation of humoral immune response mediated by circulating immunoglobulin; cell surface receptor linked signal transduction; response to bacterium; positive regulation of phagocytosis; negative regulation of immunoglobulin production; immune complex clearance; negative regulation of inflammatory response to antigenic stimulus; immune response; immunoglobulin mediated immune response; phagocytosis, engulfment

size1 :

0.1 mg

price1 :

205 USD

more info or order :

MyBioSource product webpage