MyBioSource

antibody

MOUSE ANTI C-MYC:FITC

MBS210873

0.1 mg

405 USD

monoclonal

mouse

FITC

human

FACS, flow cytometry

MBS210873

Antibody

MOUSE ANTI C-MYC:FITC

C-MYC

myc proto-oncogene protein; Myc proto-oncogene protein; myc proto-oncogene protein; avian myelocytomatosis viral oncogene homolog; class E basic helix-loop-helix protein 39; myc-related translation/localization regulatory factor; proto-oncogene c-Myc; transcription factor p64; v-myc myelocytomatosis viral oncogene homolog; v-myc avian myelocytomatosis viral oncogene homolog; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64

C-MYC

MYC; MYC; MRTL; MYCC; c-Myc; bHLHe39; BHLHE39; bHLHe39

MYC_HUMAN

Monoclonal

IgG1

9.00E+10

Mouse

454

FITC. Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid

IgG concentration 0.1 mg/ml

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

Flow cytometry (FC/FACS)*

Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Flow Cytometry: Maximum Dilution: Neat; Application Note: Membrane permeabilisation is required for this application. MyBioSource recommends the use of Leucoperm for this purpose.

Perservative Stabilisers: 0.09% Sodium Azide. 1% Bovine Serum Albumin. Preparation: Purified IgG prepared by affinity chromatography on Protein G

Buffer Solution: Phosphate buffered saline. Target Species: Human

Mouse anti c-myc antibody, clone 9E10 detects the p62c-myc proto-oncogene protein, which is involved in the regulation of the cell cycle and cell growth. C-myc is primarily located to the cell nucleus, but has also been shown to localised to the cytoplasm in several cell lines (Craig et al. 1993). Overexpression of c-myc has been reported in a wide variety of human cancers (Nesbit et al. 1999). Mouse anti c-myc antibody, clone 9E10 recognizes the sequence EQKLISEEDL and may be used to detect proteins and peptides labelled with molecular tags containing this sequence (Hilpert et al. 2001).

71774083

NP_002458.2

NM_002467.4

P01106

50,565 Da

Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Apoptosis Pathway 198797!!Bladder Cancer Pathway 83115!!Bladder Cancer Pathway 527!!C-MYB Transcription Factor Network Pathway 138073!!C-MYC Pathway 169344!!CD40/CD40L Signaling Pathway 138061!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]

0.1 mg

405 USD