MOUSE ANTI HUMAN CD88:FITC | MyBioSource MBS210831 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI HUMAN CD88:FITC

catalog :

MBS210831

quantity :

0.1 mg

price :

405 USD

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

P12/1

reactivity :

human

application :

flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS210831

products type :

Antibody

products full name :

MOUSE ANTI HUMAN CD88:FITC

products short name :

CD88

other names :

C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin receptor; C5a ligand; C5a-R; complement component 5 receptor 1; complement component 5a receptor 1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD_antigen: CD88

products gene name :

CD88

other gene names :

C5AR1; C5AR1; C5A; C5AR; C5R1; CD88; C5AR; C5R1; C5a-R; C5aR

uniprot entry name :

C5AR1_HUMAN

clonality :

Monoclonal

isotype :

IgG2a

clone :

P12/1

host :

Mouse

sequence length :

350

form :

FITC. Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid

concentration :

IgG concentration 0.1 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Flow cytometry (FC/FACS)

app notes :

Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Flow Cytometry: Maximum Dilution: 1/10

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide. 1% Bovine Serum Albumin. Preparation: Purified IgG prepared by ion exchange chromatography.

other info2 :

Immunogen: C5aR - peptide: Met1 - Asn31. Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the mouse X63 - Ag8 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Human

products description :

Mouse anti Human CD88 antibody, clone P12/1 recognizes the C5a receptor (C5aR) CD88, which is predominantly expressed on cells of the myeloid lineage. Clone P12/1 was raised against a synthetic peptide comprising the N-terminal extracellular domain of the C5aR (met1-Asn31). Mouse anti Human CD88 antibody, clone P12/1 does not inhibit the binding of C5a to its receptor.

ncbi gi num :

4502509

ncbi acc num :

NP_001727.1

ncbi gb acc num :

NM_001736.3

uniprot acc num :

P21730

ncbi mol weight :

39,336 Da

ncbi pathways :

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Metabolic Disorders Of Biological Oxidation Enzymes Pathway (1127637)

uniprot summary :

C5aR: a family 1 G-protein coupled receptor that stimulates the GTPase activity of Gi2. Receptor for the chemotactic and inflammatory complement factor C5a. Stimulates chemotaxis, granule enzyme release and superoxide anion production. Phosphorylated in response to C5a or after stimulation of cells with phorbol esters. Expressed on monocytes, granulocytes, dendritic cells, astrocytes and microglia. Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 19q13.3-q13.4. Cellular Component: cell surface; apical part of cell; integral to plasma membrane; basolateral plasma membrane; cytoplasmic membrane-bound vesicle; plasma membrane. Molecular Function: complement component C5a receptor activity; complement component C5a binding; C5a anaphylatoxin receptor activity. Biological Process: neutrophil chemotaxis; sensory perception of chemical stimulus; organ regeneration; apoptosis; activation of MAPK activity; response to lipopolysaccharide; cell proliferation in hindbrain; signal transduction; chemotaxis; mRNA transcription from RNA polymerase II promoter; defense response to Gram-positive bacterium; elevation of cytosolic calcium ion concentration; phospholipase C activation; response to peptidoglycan; cellular defense response; immune response; negative regulation of neuron apoptosis; inflammatory response; positive regulation of epithelial cell proliferation

size1 :

0.1 mg

price1 :

405 USD

more info or order :

MyBioSource product webpage