RAT ANTI MOUSE INTERLEUKIN-2:FITC | MyBioSource MBS210650 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RAT ANTI MOUSE INTERLEUKIN-2:FITC

catalog :

MBS210650

quantity :

0.1 mg

price :

285 USD

clonality :

monoclonal

host :

rat

conjugate :

FITC

clone name :

JES6-5H4

reactivity :

mouse

application :

flow cytometry, FACS

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS210650

products type :

Antibody

products full name :

RAT ANTI MOUSE INTERLEUKIN-2:FITC

products short name :

IL-2

other names :

interleukin-2; Interleukin-2; interleukin-2; T-cell growth factor; TCGF; interleukin 2; T-cell growth factor; TCGF

other gene names :

Il2; Il2; Il-2; Il-2; IL-2; TCGF

uniprot entry name :

IL2_MOUSE

clonality :

Monoclonal

isotype :

IgG2b

clone :

JES6-5H4

host :

Rat

sequence length :

169

form :

FITC. Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid

concentration :

IgG concentration 0.1 mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Flow cytometry (FC/FACS)*

app notes :

Flow Cytometry: Minimum Dilution: Neat; Maximum Dilution: 1/10; Application Note: Membrane permeabilization is required for this application. MyBioSource recommends the use of Leucoperm for this purpose.

other info1 :

Perservative Stabilisers: 0.09% Sodium Azide. 1% Bovine Serum Albumin. Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

other info2 :

Immunogen: Recombinant Mouse IL-2. Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the mouse P3.X63 Ag8.653 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Mouse

products description :

Rat anti Mouse Interleukin-2 antibody, clone JES6-5H4 recognizes natural and recombinant murine IL-2. Rat anti Mouse Interleukin-2 antibody, clone JES6-5H4 does not function as a blocking antibody (Sander et al. 1993). For neutralization of murine IL-2, MyBioSource recommend the use of clone JES6-1A12).

ncbi gi num :

7110653

ncbi acc num :

NP_032392.1

ncbi gb acc num :

NM_008366.3

uniprot acc num :

P04351

ncbi mol weight :

19,400 Da

ncbi pathways :

Allograft Rejection Pathway (83316); Allograft Rejection Pathway (535); Autoimmune Thyroid Disease Pathway (83314); Autoimmune Thyroid Disease Pathway (533); Chagas Disease (American Trypanosomiasis) Pathway (147810); Chagas Disease (American Trypanosomiasis) Pathway (147795); Cytokine Signaling In Immune System Pathway (1110778); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); Cytokines And Inflammatory Response (BioCarta) Pathway (198283)

uniprot summary :

IL2: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family. Protein type: Oncoprotein; Secreted; Cytokine; Secreted, signal peptide. Cellular Component: extracellular space; cell; extracellular region; cytosol. Molecular Function: growth factor activity; interleukin-2 receptor binding; cytokine activity; glycosphingolipid binding; carbohydrate binding; kappa-type opioid receptor binding. Biological Process: positive regulation of interleukin-17 production; positive regulation of isotype switching to IgG isotypes; regulation of T cell homeostatic proliferation; positive regulation of regulatory T cell differentiation; negative regulation of heart contraction; immune system process; positive regulation of immunoglobulin secretion; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; G-protein coupled receptor protein signaling pathway; positive regulation of interferon-gamma production; elevation of cytosolic calcium ion concentration; positive regulation of T cell differentiation; negative regulation of protein amino acid phosphorylation; positive regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of inflammatory response; protein kinase C activation; positive regulation of B cell proliferation; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of T cell proliferation; positive regulation of protein amino acid phosphorylation; negative regulation of B cell apoptosis

size1 :

0.1 mg

price1 :

285 USD

more info or order :

MyBioSource product webpage