Botin-Linked Monoclonal Antibody to Tumor Necrosis Factor Beta (TNFb) | MyBioSource MBS2106339 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Botin-Linked Monoclonal Antibody to Tumor Necrosis Factor Beta (TNFb)

catalog :

MBS2106339

quantity :

0.1 mg

price :

190 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[C6]

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2106339

products type :

Antibody

products full name :

Botin-Linked Monoclonal Antibody to Tumor Necrosis Factor Beta (TNFb)

products short name :

[Tumor Necrosis Factor Beta (TNFb)]

products name syn :

[LT; LTA; TNF-B; TNFSF1; Tumor Necrosis Factor Ligand Superfamily Member 1; Lymphotoxin Alpha]

other names :

[lymphotoxin alpha, partial; Lymphotoxin-alpha; lymphotoxin-alpha; lymphotoxin alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1]

products gene name :

[TNFb]

other gene names :

[LTA; LTA; LT; TNFB; TNFSF1; TNLG1E; TNFB; TNFSF1; LT-alpha]

uniprot entry name :

TNFB_HUMAN

clonality :

clone :

[C6]

host :

Mouse

purity :

Protein A/G Affinity Chromatography.

form :

Supplied as solution form in PBS, pH7.4, 50% glycerol 0.05% Proclin-300.

concentration :

0.36mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 24 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

app notes :

Western blotting: 0.5-2ug/mL;. Immunohistochemistry: 5-20ug/mL;. Immunocytochemistry: 5-20ug/mL;. Optimal working dilutions must be determined by end user.

other info1 :

Organism Species: Homo sapiens (Human). Source: Monoclonal antibody preparation. Label: Biotin. Traits: Liquid. Immunogen: Recombinant TNFb (Pro35~Leu205) expressed in E.coli.

ncbi gi num :

31880318

ncbi acc num :

AAP51435.1

uniprot acc num :

P01374

ncbi pathways :

Apoptosis Pathway (198797); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Herpes Simplex Infection Pathway (377873); Herpes Simplex Infection Pathway (377865); IL2 Signaling Events Mediated By STAT5 Pathway (137988); IL4-mediated Signaling Events Pathway (137933); NF-kappa B Signaling Pathway (634527)

ncbi summary :

The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

uniprot summary :

LTA: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS). PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). Belongs to the tumor necrosis factor family. Protein type: Secreted; Cytokine; Apoptosis; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: extracellular space; membrane. Molecular Function: cytokine activity; tumor necrosis factor receptor binding; receptor binding. Biological Process: response to drug; positive regulation of humoral immune response mediated by circulating immunoglobulin; apoptosis; positive regulation of apoptosis; response to lipopolysaccharide; signal transduction; lymph node development; humoral immune response; defense response to Gram-positive bacterium; positive regulation of interferon-gamma production; cell-cell signaling; negative regulation of fibroblast proliferation; response to hypoxia; positive regulation of chronic inflammatory response to antigenic stimulus; response to nutrient. Disease: Psoriatic Arthritis, Susceptibility To; Myocardial Infarction, Susceptibility To; Leprosy, Susceptibility To, 4

size1 :

0.1 mg

price1 :

190 USD

size2 :

0.2 mg

price2 :

245

size3 :

1 mg

price3 :

560

more info or order :

MyBioSource product webpage