antibody

MOUSE ANTI HUMAN ZAP 70:FITC

MBS210582

0.1 mg

380 USD

monoclonal

mouse

FITC

SBZAP

flow cytometry, FACS

Antibody

MOUSE ANTI HUMAN ZAP 70:FITC

ZAP 70

tyrosine-protein kinase ZAP-70 isoform 1; Tyrosine-protein kinase ZAP-70; tyrosine-protein kinase ZAP-70; 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; syk-related tyrosine kinase; zeta-chain associated protein kinase, 70kD; zeta-chain (TCR) associated protein kinase 70kDa; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase

ZAP 70

ZAP70; ZAP70; SRK; STD; TZK; STCD; ZAP-70; SRK

ZAP70_HUMAN

Monoclonal

IgG1

SBZAP

Mouse

619

FITC. Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid

IgG concentration 0.1 mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

Flow cytometry (FC/FACS)*

Flow Cytometry: Application Note: Membrane permeabilisation is required for this application. MyBioSource recommends the use of Leucoperm

Perservative Stabilisers: 0.1% Sodium azide

Immunogen: Peptide corresponding to amino acid residues 280-309 of human ZAP-70, conjugated to KLH. Buffer Solution: Phosphate buffered saline. Target Species: Human

Mouse anti Human ZAP 70 antibody, clone SBZAP recognizes human ZAP-70, a 70kDa tyrosine protein kinase which associates with the T-cell receptor (TCR) zeta chain and undergoes phosphorylation following TCR stimulation. ZAP-70 is primarily expressed in T lymphocytes and natural killer cells, where it plays a key role in T-cell receptor (TCR) signalling. Recent studies suggest that ZAP-70 is also expressed in a population of normal immature B-cells and in B-cells from a sub-set of patients with chronic lymphocytic leukaemia.

31455611

NP_001070.2

NM_001079.3

P43403

55,873 Da

Adaptive Immune System Pathway 366160!!B Cell Receptor Signaling Pathway 198909!!Generation Of Second Messenger Molecules Pathway 106417!!Immune System Pathway 106386!!Inflammatory Response Pathway 198766!!Interferon Type I Pathway 920993!!NF-kappa B Signaling Pathway 634527!!Natural Killer Cell Mediated Cytotoxicity Pathway 83079!!Natural Killer Cell Mediated Cytotoxicity Pathway 490!!Primary Immunodeficiency Pathway 83125

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

0.1 mg

380 USD