protein

Recombinant Purinergic Receptor P2X, Ligand Gated Ion Channel 4 (P2RX4)

MBS2105554

0.01 mg

165 USD

Recombinant Protein

Recombinant Purinergic Receptor P2X, Ligand Gated Ion Channel 4 (P2RX4)

[Purinergic Receptor P2X, Ligand Gated Ion Channel 4 (P2RX4)]

[P2X4; P2X4R; P2X Purinoceptor 4; ATP receptor; Purinergic receptor]

[P2X purinoceptor 4; P2X purinoceptor 4; P2X purinoceptor 4; purinergic receptor P2X 4; ATP receptor; Purinergic receptor]

[P2RX4]

[P2RX4; P2RX4; P2X4; P2X4R; P2X4]

P2RX4_HUMAN

E.coli

> 90%

20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose.

Original Concentration: 300ug/mL

Storage:. Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Stability Test:. The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Positive Control, Immunogen, SDS-PAGE, Western Blot (WB).

Sequence

SDS-PAGE

Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Asn75~Asn338. Tags: N-terminal His Tag. Subcellular Location: Membrane. Traits: Freeze-dried powder

Predicted isoelectric point: 7.6. Usage: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

CD & Adhesion Molecule

116242696

Q99571.2

Q99571

Predicted Molecular Mass: 33.2kDa. Accurate Molecular Mass: 33kDa as determined by SDS-PAGE reducing conditions.

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462)

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

P2X4: Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. Belongs to the P2X receptor family. Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral. Chromosomal Location of Human Ortholog: 12q24.32. Cellular Component: membrane; cell soma; perinuclear region of cytoplasm; apical part of cell; lysosomal membrane; integral to plasma membrane; postsynaptic density; dendritic spine; plasma membrane; terminal button; integral to nuclear inner membrane; cell junction. Molecular Function: protein homodimerization activity; copper ion binding; zinc ion binding; cadherin binding; drug binding; ATP binding; purinergic nucleotide receptor activity; ATP-gated cation channel activity; receptor binding. Biological Process: positive regulation of nitric oxide biosynthetic process; generation of action potential; positive regulation of calcium-mediated signaling; regulation of sodium ion transport; sensory perception of pain; signal transduction; vasodilation; response to ATP; endothelial cell activation; membrane depolarization; transport; calcium ion transport; regulation of blood pressure; positive regulation of prostaglandin secretion; tissue homeostasis; regulation of excitatory postsynaptic membrane potential; positive regulation of calcium ion transport; nitric oxide biosynthetic process; protein homooligomerization

0.01 mg

165 USD

0.05 mg

335

0.1 mg

515

0.2 mg

635

0.5 mg

1235

1 mg

1845