product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
MOUSE ANTI HUMAN MESOTHELIN
catalog :
MBS210090
quantity :
1 mL
price :
1190 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
[K1]
reactivity :
human, cow
application :
immunohistochemistry, immunohistochemistry - frozen section
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS210090
products type :
Antibody
products full name :
MOUSE ANTI HUMAN MESOTHELIN
products short name :
[MESOTHELIN]
other names :
[mesothelin isoform 1 preproprotein; Mesothelin; mesothelin; CAK1 antigen; megakaryocyte potentiating factor; pre-pro-megakaryocyte-potentiating factor; soluble MPF mesothelin related protein; mesothelin; CAK1 antigen; Pre-pro-megakaryocyte-potentiating factorCleaved into the following 2 chains:Megakaryocyte-potentiating factor; MPF; Mesothelin, cleaved form]
other gene names :
[MSLN; MSLN; MPF; SMRP; MPF; MPF]
uniprot entry name :
MSLN_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
[K1]
host :
Mouse
reactivity :
Cynomolgus monkey. N.B. Antibody reactivity and working conditions may vary between species.
sequence length :
622
form :
Concentrate. Ascitic Fluid - Diluted
storage stability :
Store at 4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
Immunohistology Frozen
app notes :
Immunohistology - Frozen: 1/10; 1/40
other info1 :
Perservative Stabilisers: 0.1% Sodium Azide (NaN3). 1% Bovine Serum Albumin. Immunogen: Spleen lymphocytes from mice fused with the ovcar-3 ovarian carcinoma cell line.
other info2 :
Histology Positive Control Tissue: Human tonsil or lymph node. Buffer Solution: Phosphate buffered saline. Target Species: Human
products description :
Mouse anti Human Mesothelin, clone K1, recongnizes a 40kDa GPI-anchored cell surface glycoprotein also known as CAK1. Mesothelin is a differentiation antigen present on normal mesothelial cells and overexpressed in several human tumors, including mesothelioma; ovarian and pancreatic adenocarcinoma. Mesothelin is attached to the cell membrane by a glycosylphosphatidyl inositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF). Clone K1 antibody has been used to differentiate between epithelial malignant mesothelioma and lung adenocarcinomas by immunohistology.
ncbi gi num :
293651530
ncbi acc num :
NP_001170826.1
ncbi gb acc num :
NM_001177355.1
uniprot acc num :
Q13421
ncbi summary :
This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
uniprot summary :
MSLN: Membrane-anchored forms may play a role in cellular adhesion. Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. Belongs to the mesothelin family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion; Membrane protein, GPI anchor. Chromosomal Location of Human Ortholog: 16p13.3. Cellular Component: Golgi apparatus; extracellular space; cell surface; membrane; plasma membrane. Molecular Function: protein binding. Biological Process: pancreas development; cell adhesion
size1 :
1 mL
price1 :
1190 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!