MOUSE ANTI HUMAN COLLAGEN II | MyBioSource MBS210037 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MOUSE ANTI HUMAN COLLAGEN II

catalog :

MBS210037

quantity :

0.1 mL

price :

610 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[COLL-II]

reactivity :

human, mouse, rat, dog, cow

application :

western blot, ELISA, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS210037

products type :

Antibody

products full name :

MOUSE ANTI HUMAN COLLAGEN II

products short name :

[COLLAGEN II]

other names :

[collagen alpha-1(II) chain isoform 1; Collagen alpha-1(II) chain; collagen alpha-1(II) chain; collagen alpha-1(II) chain; alpha-1 type II collagen; arthroophthalmopathy, progressive (Stickler syndrome); cartilage collagen; chondrocalcin; collagen II, alpha-1 polypeptide; collagen, type II, alpha 1; Alpha-1 type II collagenCleaved into the following 2 chains:Collagen alpha-1(II) chain; Chondrocalcin]

other gene names :

[COL2A1; COL2A1; AOM; ANFH; SEDC; STL1; COL11A3]

uniprot entry name :

CO2A1_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

[COLL-II]

host :

Mouse

reactivity :

Rat, Bovine, Sheep, Mouse, Dog ,Pig. N.B. Antibody reactivity and working conditions may vary between species.

sequence length :

1487

specificity :

COLLAGEN II

form :

Ascites - liquid

storage stability :

Store at -20°C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

ELISA, Western Blotting, Immunofluorescence

app notes :

ELISA; 1/100-1/500. Western Blotting ; 1/100-1/2000. Immunofluorescence; Neat-1/5

other info1 :

Immunogen: Human ( cartilage specific) CNBr-cleaved collagen 2. Preservative Stabilizers: None present.

other info2 :

Target Species: Human

products description :

Mouse anti Collagen II antibody, clone COLL-II recognizes human collagen type II, the main collagen in cartilaginous tissue. Mouse anti Collagen II antibody, clone COLL-II reacts with both pepsin solubilised and CNBr-cleaved human and bovine collagen type II. No-cross reactivity is seen with types I, III, V or IX.

ncbi gi num :

111118976

ncbi acc num :

NP_001835.3

ncbi gb acc num :

NM_001844.4

uniprot acc num :

P02458

ncbi pathways :

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Collagen Biosynthesis And Modifying Enzymes Pathway (645289); Collagen Formation Pathway (645288); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Endochondral Ossification Pathway (198812); Extracellular Matrix Organization Pathway (576262); Focal Adhesion Pathway (198795)

ncbi summary :

This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

COL2A1: the alpha-1 chain of type II collagen, an extra-cellular matrix protein found in cartilage and the vitreous humor of the eye. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Chondrocalcin is the calcium binding C-propeptide of this collagen molecule. Defects in this protein are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. There are two transcripts identified for this gene. Belongs to the fibrillar collagen family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Extracellular matrix; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 12q13.11. Cellular Component: extracellular matrix; extracellular space; endoplasmic reticulum lumen; collagen type II; extracellular region; basement membrane. Molecular Function: identical protein binding; platelet-derived growth factor binding; metal ion binding; extracellular matrix structural constituent conferring tensile strength. Biological Process: heart morphogenesis; axon guidance; proteoglycan metabolic process; extracellular matrix organization and biogenesis; inner ear morphogenesis; central nervous system development; collagen fibril organization; palate development; notochord development; limb bud formation; collagen catabolic process; extracellular matrix disassembly; sensory perception of sound; visual perception; regulation of gene expression; cartilage development; tissue homeostasis; chondrocyte differentiation; skeletal development; endochondral ossification; cartilage condensation. Disease: Achondrogenesis, Type Ii; Kniest Dysplasia; Spondyloperipheral Dysplasia; Epiphyseal Dysplasia, Multiple, With Myopia And Conductive Deafness; Legg-calve-perthes Disease; Osteoarthritis With Mild Chondrodysplasia; Stickler Syndrome, Type I; Czech Dysplasia; Platyspondylic Lethal Skeletal Dysplasia, Torrance Type; Otospondylomegaepiphyseal Dysplasia; Spondyloepimetaphyseal Dysplasia, Strudwick Type; Avascular Necrosis Of Femoral Head, Primary; Spondyloepiphyseal Dysplasia Congenita; Stickler Syndrome, Type I, Nonsyndromic Ocular

size1 :

0.1 mL

price1 :

610 USD

more info or order :

MyBioSource product webpage