Biotin-Linked Polyclonal Antibody to Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) | MyBioSource MBS2096298 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Biotin-Linked Polyclonal Antibody to Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1)

catalog :

MBS2096298

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

biotin

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2096298

products type :

Antibody

products full name :

Biotin-Linked Polyclonal Antibody to Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1)

products short name :

[Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1)]

products name syn :

[PARK5; PGP9.5; Uch-L1; Neuron cytoplasmic protein 9.5; Ubiquitin thioesterase L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1]

other names :

[ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin C-terminal hydrolase L1; Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; Ubiquitin thioesterase L1]

products gene name :

[UCHL1]

other gene names :

[UCHL1; UCHL1; NDGOA; PARK5; PGP95; SPG79; PGP9.5; Uch-L1; HEL-117; PGP 9.5; HEL-S-53; UCH-L1; PGP9.5]

clonality :

polyclonal

host :

rabbit

sequence length :

223

purity :

Antigen-specific Affinity Chromatography.

form :

Supplied as solution form in PBS, pH7.4, 50% glycerol 0.05% Proclin-300.

concentration :

0.43 mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 24 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

app notes :

Western blotting: 0.5-2ug/mL;. Immunohistochemistry: 5-20ug/mL;. Immunocytochemistry: 5-20ug/mL;. Optimal working dilutions must be determined by end user.

other info1 :

Organism Species: Homo sapiens (Human). Source: Antibody labeling. Label: Biotin. Traits: Liquid. Immunogen: Recombinant UCHL1 (Gln2~Ala223) expressed in E.coli.

ncbi gi num :

21361091

ncbi acc num :

NP_004172.2

ncbi gb acc num :

NM_004181.4

uniprot acc num :

P09936

ncbi pathways :

Alpha-synuclein Signaling Pathway (137913); Parkinson's Disease Pathway (83098); Parkinsons Disease Pathway (705377); Proteasome Degradation Pathway (198786)

ncbi summary :

The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]

uniprot summary :

UCHL1: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. Monomer. Homodimer. Interacts with SNCA. Interacts with COPS5. Found in neuronal cell bodies and processes throughout the neocortex. Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. Belongs to the peptidase C12 family. Protein type: Cell development/differentiation; EC 3.4.19.12; Ligase; Protease; Ubiquitin conjugating system. Chromosomal Location of Human Ortholog: 4p13. Cellular Component: axon cytoplasm; cell soma; cytoplasm; cytosol; endoplasmic reticulum membrane; extracellular exosome; myelin sheath; neuron projection terminus; nucleoplasm; plasma membrane. Molecular Function: alpha-2A adrenergic receptor binding; cysteine-type endopeptidase activity; ligase activity; omega peptidase activity; protein binding; thiol-dependent ubiquitin-specific protease activity; thiol-dependent ubiquitinyl hydrolase activity; ubiquitin binding; ubiquitin protein ligase binding. Biological Process: adult walking behavior; axon target recognition; axonal transport of mitochondrion; cell proliferation; eating behavior; muscle fiber development; negative regulation of MAP kinase activity; neuromuscular process; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; regulation of macroautophagy; sensory perception of pain. Disease: Neurodegeneration With Optic Atrophy, Childhood-onset; Parkinson Disease 5, Autosomal Dominant

size1 :

0.1 mg

price1 :

245 USD

size2 :

0.2 mg

price2 :

370

size3 :

1 mg

price3 :

880

more info or order :

MyBioSource product webpage