antibody

Biotin-Linked Polyclonal Antibody to Solute Carrier Family 3, Member 2 (SLC3A2)

MBS2095713

0.1 mg

245 USD

polyclonal

rabbit

biotin

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

Antibody

Biotin-Linked Polyclonal Antibody to Solute Carrier Family 3, Member 2 (SLC3A2)

[Solute Carrier Family 3, Member 2 (SLC3A2)]

[SLC3A2; CD98HC; 4F2; 4F2HC; 4T2HC; MDU1; NACAE; Activators Of Dibasic And Neutral Amino Acid Transport; Antigen Identified By Monoclonal Antibodies 4F2; CD98 Heavy Chain]

[solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2, isoform CRA_d; 4F2 cell-surface antigen heavy chain; 4F2 cell-surface antigen heavy chain; solute carrier family 3 member 2; 4F2 heavy chain antigen; Lymphocyte activation antigen 4F2 large subunit; Solute carrier family 3 member 2; CD_antigen: CD98]

[SLC3A2]

[SLC3A2; SLC3A2; 4F2; CD98; MDU1; 4F2HC; 4T2HC; NACAE; CD98HC; MDU1; 4F2hc]

Polyclonal

Rabbit

Antigen-specific Affinity Chromatography.

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

0.51mg/ml

Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Western blotting: 0.5-2 ug/mL;1:250-1000. Immunohistochemistry: 5-20 ug/mL;1:25-100. Immunocytochemistry: 5-20 ug/mL;1:25-100. Optimal working dilutions must be determined by end user.

Organism Species: Homo sapiens (Human). Source: Antibody labeling. Label: Biotin. Traits: Liquid

Immunogen: Recombinant SLC3A2 (Leu270~Arg406) expressed in E.coli.

119594527

EAW74121.1

Amino Acid Transport Across The Plasma Membrane Pathway (1269916); Basigin Interactions Pathway (1269376); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Cell Surface Interactions At The Vascular Wall Pathway (1269373); Ferroptosis Pathway (1510435); Ferroptosis Pathway (1510200); Hemostasis Pathway (1269340); Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway (1309221); Metabolism Pathway (1269956); Metabolism Of Amino Acids And Derivatives Pathway (1270158)

This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]

SLC3A2: a transmembrane solute carrier protein that transports L-type amino acids and regulates intracellular calcium levels. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier. Disulfide-linked heterodimer of a glycosylated heavy chain and a non-glycosylated light chain (SLC7A5, SLC7A6, SLCA7A7, SLC7A8, SLC7A10 or SLCA7A11). Colocalizes with cadherins. Interacts with FAM57A and ICAM1. Constitutively and specifically associates with beta-1 integrins (alpha-2/beta-1, alpha-3/beta-1, alpha-5/beta-1 and alpha-6/beta-1), but minimally with alpha-4/beta-1. Expression is induced in resting peripheral blood T- lymphocytes following PHA stimulation. Expression increases at the time of maximal DNA synthesi, in fibroblasts stimulated to divide. Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore. Expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta was significantly stronger at full-term than at the mid- trimester stage. Belongs to the SLC3A transporter family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Transporter. Chromosomal Location of Human Ortholog: 11q12.3. Cellular Component: apical plasma membrane; cell surface; cytosol; integral component of membrane; melanosome; membrane; nucleus; plasma membrane. Molecular Function: cadherin binding; calcium:sodium antiporter activity; catalytic activity; double-stranded RNA binding; neutral amino acid transmembrane transporter activity; protein binding; RNA binding. Biological Process: amino acid transport; calcium ion transport; carbohydrate metabolic process; cell growth; leukocyte migration; response to exogenous dsRNA; tryptophan transport

0.1 mg

245 USD

0.2 mg

370

1 mg

880