Biotin-Linked Polyclonal Antibody to Interleukin 6 Receptor (IL6R) | MyBioSource MBS2093809 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Biotin-Linked Polyclonal Antibody to Interleukin 6 Receptor (IL6R)

catalog :

MBS2093809

quantity :

0.1 mg

price :

250 USD

clonality :

polyclonal

host :

rabbit

conjugate :

biotin

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2093809

products type :

Antibody

products full name :

Biotin-Linked Polyclonal Antibody to Interleukin 6 Receptor (IL6R)

products short name :

[Interleukin 6 Receptor (IL6R)]

products name syn :

[CD126; gp80; IL6R; IL-6R-1; IL-6R-Alpha; IL6RA; IL-6 receptor subunit alpha; Membrane glycoprotein 80]

other names :

[Interleukin 6 receptor; Interleukin-6 receptor subunit alpha; interleukin-6 receptor subunit alpha; interleukin 6 receptor; IL-6R 1; Membrane glycoprotein 80; gp80; CD_antigen: CD126]

products gene name :

[IL6R]

other gene names :

[IL6R; IL6R; IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; gp80]

clonality :

Polyclonal

host :

Rabbit

sequence length :

468

purity :

Antigen-specific Affinity Chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

concentration :

0.45 mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Western blot (WB),Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP).

app notes :

Western blotting: 0.5-2 ug/mL;1:220-900. Immunohistochemistry: 5-20 ug/mL;1:22-90. Immunocytochemistry: 5-20 ug/mL;1:22-90. Optimal working dilutions must be determined by end user

other info1 :

Organism Species: Rattus norvegicus (Rat). Source: Antibody labeling. Label: Biotin. Traits: Liquid. Immunogen: Recombinant IL6R (Asp214~Ala348) expressed in E.coli.

ncbi gi num :

124375840

ncbi acc num :

AAI32687.1

ncbi pathways :

Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); HIF-1 Signaling Pathway (695200); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); IL-6 Signaling Pathway (198864); IL6-mediated Signaling Events Pathway (137932); Immune System Pathway (106386); Interleukin-6 Signaling Pathway (205111)

ncbi summary :

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]

uniprot summary :

IL6R: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, cytokine. Chromosomal Location of Human Ortholog: 1q21.3. Cellular Component: apical plasma membrane; basolateral plasma membrane; cell surface; extracellular region; interleukin-6 receptor complex; plasma membrane. Molecular Function: ciliary neurotrophic factor receptor activity; enzyme binding; interleukin-6 binding; interleukin-6 receptor activity; interleukin-6 receptor binding; protein binding; protein homodimerization activity. Biological Process: acute-phase response; cytokine-mediated signaling pathway; defense response to Gram-negative bacterium; endocrine pancreas development; hepatic immune response; monocyte chemotaxis; positive regulation of cell proliferation; positive regulation of chemokine production; positive regulation of interleukin-6 production; positive regulation of leukocyte chemotaxis; positive regulation of osteoblast differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; response to cytokine. Disease: Interleukin 6, Serum Level Of, Quantitative Trait Locus; Soluble Interleukin-6 Receptor, Serum Level Of, Quantitative Trait Locus

size1 :

0.1 mg

price1 :

250 USD

size2 :

0.2 mg

price2 :

380

size3 :

1 mg

price3 :

910

more info or order :

MyBioSource product webpage