antibody

Biotin-Linked Monoclonal Antibody to Vascular Endothelial Growth Factor A (VEGFA)

MBS2090797

0.1 mg

170 USD

monoclonal

mouse

biotin

[C12]

western blot, immunohistochemistry, immunocytochemistry

Antibody

Biotin-Linked Monoclonal Antibody to Vascular Endothelial Growth Factor A (VEGFA)

[Vascular Endothelial Growth Factor A (VEGFA)]

[vascular endothelial growth factor A isoform VEGF-A; Vascular endothelial growth factor A; vascular endothelial growth factor A; Vascular permeability factor; VPF]

[VEGFA]

[VEGFA; VEGFA; VPF; VEGF; VEGF-A; eVEGF120; eVEGF164; VEGF; VEGF-A; VPF]

m

[C12]

Mouse

Protein A + Protein G affinity chromatography

Supplied as solution form in PBS, pH7.4, 50% glycerol 0.05% Proclin-300.

0.7mg/ml

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 24 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Western blotting: 0.5-2ug/mL. Immunohistochemistry: 5-20ug/mL. Immunocytochemistry: 5-20ug/mL. Optimal working dilutions must be determined by end user.

Organism Species: Homo sapiens (Human). Source: Monoclonal antibody preparation. Label: Biotin. Traits: Liquid. Immunogen: Recombinant VEGFA (Pro28~Asp191) expressed in E.coli.

27806357

NP_776641.1

NM_174216.2

P15691

Bladder Cancer Pathway (84350); Bladder Cancer Pathway (527); Cytokine-cytokine Receptor Interaction Pathway (84290); Cytokine-cytokine Receptor Interaction Pathway (460); Focal Adhesion Pathway (84306); Focal Adhesion Pathway (478); HIF-1 Signaling Pathway (695207); Id Signaling Pathway (198561); MicroRNAs In Cancer Pathway (852708); MicroRNAs In Cancer Pathway (852928)

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. It is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. [provided by RefSeq, Nov 2015]

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development ().

0.1 mg

170 USD

0.2 mg

220

1 mg

485