antibody

Polyclonal Antibody to Procollagen III N-Terminal Propeptide (PIIINP)

MBS2090489

0.01 mg

115 USD

polyclonal

rabbit

nonconjugated

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

Antibody

Polyclonal Antibody to Procollagen III N-Terminal Propeptide (PIIINP)

[Procollagen III N-Terminal Propeptide (PIIINP)]

[P3NP; N-Propeptide Of Type III Procollagen; Procollagen III Amino Terminal Propeptide]

[collagen alpha-1(III) chain preproprotein; Collagen alpha-1(III) chain; collagen alpha-1(III) chain; collagen, type III, alpha 1]

[PIIINP]

[Col3a1; Col3a1; Tsk2; Tsk-2; Col3a-1; AW550625]

Polyclonal

Rabbit

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

1 mg/ml

Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP).

Western blotting: 0.5-2 ug/mL;1:500-2000. Immunohistochemistry: 5-20 ug/mL;1:50-200. Immunocytochemistry: 5-20 ug/mL;1:50-200. Optimal working dilutions must be determined by end user.

Western Blot (WB)

Organism Species: Mus musculus (Mouse). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant PIIINP expressed in E.coli.

226423933

NP_034060.2

NM_009930.2

P08121

Amoebiasis Pathway (167330); Amoebiasis Pathway (167191); Axon Guidance Pathway (366334); Cell Surface Interactions At The Vascular Wall Pathway (366331); Collagen Adhesion Via GPVI Pathway (366298); Collagen Adhesion Via Gp IV Pathway (366296); Collagen Adhesion Via Alpha 2 Beta 1 Glycoprotein Pathway (366295); ECM-receptor Interaction Pathway (83265); ECM-receptor Interaction Pathway (479); Focal Adhesion Pathway (198353)

This gene encodes the alpha-1 subunit of the fibril-forming type III collagen found in bone, cartilage, dentin, tendon, bone marrow stroma and other connective tissue. The encoded protein forms homotrimeric type III procollagen that undergoes proteolytic processing during fibril formation. A majority of mice lacking the encoded protein die within two days of birth but about 5% of the animals survive to adulthood. The surviving mice exhibit severe cortical malformation and experience significantly shorter lifespan. The mutant mouse named "tight skin 2" exhibiting systemic sclerosis phenotype was found to harbor a missense point mutation in this gene. A pseudogene of this gene has been defined on chromosome 8. [provided by RefSeq, Nov 2015]

CO3A1: Collagen type III occurs in most soft connective tissues along with type I collagen. Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type 3 (EDS3); also known as benign hypermobility syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS3 is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity. Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type 4 (EDS4). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS4 is the most severe form of the disease. It is characterized by the joint and dermal manifestations as in other forms of the syndrome, characteristic facial features (acrogeria) in most patients, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas. Defects in COL3A1 are a cause of susceptibility to aortic aneurysm abdominal (AAA). AAA is a common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells. Belongs to the fibrillar collagen family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion; Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1 C1.1 1 23.67 cM. Cellular Component: collagen; collagen type III trimer; extracellular matrix; extracellular region; extracellular space; proteinaceous extracellular matrix. Molecular Function: extracellular matrix structural constituent; integrin binding; metal ion binding; platelet-derived growth factor binding; protease binding; SMAD binding. Biological Process: blood vessel development; cell-matrix adhesion; cerebral cortex development; collagen fibril organization; gut development; heart development; integrin-mediated signaling pathway; negative regulation of immune response; negative regulation of neuron migration; peptide cross-linking; positive regulation of Rho protein signal transduction; response to cytokine; response to radiation; skin development; transforming growth factor beta receptor signaling pathway; wound healing

0.01 mg

115 USD

0.02 mg

135

0.05 mg

190

0.1 mg

245

0.2 mg

365

1 mg

870