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Filamin A Alpha (FLNa) Antibody Pair Kit (with Standard)

MBS2090267

5 x96 Tests

1030 USD

Antibody Pair Kit

Filamin A Alpha (FLNa) Antibody Pair Kit (with Standard)

[Filamin A Alpha (FLNa)]

[ABP280; FLN-A; ABPX; FLN; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; Actin Binding Protein 280; Endothelial actin-binding protein; Filamin-1; Non-muscle filamin]

[filamin A, alpha (actin binding protein 280), isoform CRA_c; Filamin-A; filamin-A; filamin A; Actin-binding protein 280; ABP-280; Alpha-filamin; Endothelial actin-binding protein; Filamin-1; Non-muscle filamin]

[FLNa]

[FLNA; FLNA; FLN; FMD; MNS; OPD; ABPX; CSBS; CVD1; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280; FLN; FLN1; FLN-A; ABP-280]

Human

ELISA (EIA), Chemiluminescence Immunoassays (CLIA), ELISPOT, Luminex

Typical Testing Data/Standard Curve (for reference only)

Samples: Serum, Plasma, Tissue Homogenates, Cell Lysates, Cell Culture Supernates and Other Biological Fluids. Detection Range: 3.76-240ng/mL

Standard: Recombinant FLNa (Lyophilized, 1 vial-10ug). Capture Antibody: Rabbit polyclonal antibody (Liquid, 1 vial-400mug/800muL). Detection Antibody: Biotinylated Rabbit polyclonal antibody (Liquid, 1 vial-100mug/500muL). Producte Usage: Raw materials can be used for preparation of 5x96T or 10x96T ELISA Kits. Antibody Support Pack: Antibody Support Pack (Buffer Pack) is sold separately as catalog #MBS2090685

Developmental science

119593152

EAW72746.1

280,018 Da

Androgen Receptor Signaling Pathway (198806); Cell Junction Organization Pathway (160966); Cell-Cell Communication Pathway (477132); Cell-extracellular Matrix Interactions Pathway (160967); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); GP1b-IX-V Activation Signalling Pathway (187205); Hemostasis Pathway (106028); MAPK Signaling Pathway (198779)

The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance ().

5 x96 Tests

1030 USD

5x96 Tests + MBS2090685 (Ab Pairs Support Pack 1, 5x96 Tests)

1090

10x96 Tests

1645

10x96 Tests + MBS2090685 (Ab Pairs Support Pack 1, 10x96 Tests)

1765