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Vascular Endothelial Growth Factor 121 (VEGF121) Antibody Pair Kit (with Standard)

MBS2090203

5 x96 Tests

685 USD

Antibody Pair Kit

Vascular Endothelial Growth Factor 121 (VEGF121) Antibody Pair Kit (with Standard)

[Vascular Endothelial Growth Factor 121 (VEGF121)]

[vascular endothelial growth factor isoform 121; Vascular endothelial growth factor A; vascular endothelial growth factor A; vascular endothelial growth factor A; Vascular permeability factor; VPF]

[VEGF121]

[VEGFA; VEGFA; VPF; VEGF; MVCD1; VEGF; VEGF-A; VPF]

Human

ELISA (EIA), Chemiluminescence Immunoassays (CLIA), ELISPOT, Luminex

Typical Testing Data/Standard Curve (for reference only)

Samples: Serum, Plasma, Tissue Homogenates, Cell Lysates, Cell Culture Supernates and Other Biological Fluids. Detection Range: 31.2-2000pg/mL

Standard: Recombinant VEGF121 (Lyophilized, 1 vial-10ug). Capture Antibody: Mouse monoclonal antibody (Liquid, 1 vial-400mug/800muL). Detection Antibody: Biotinylated Mouse monoclonal antibody (Liquid, 1 vial-100mug/500muL). Producte Usage: Raw materials can be used for preparation of 5x96T or 10x96T ELISA Kits. Antibody Support Pack: Antibody Support Pack (Buffer Pack) is sold separately as catalog #MBS2090685

Cytokine; Signal transduction; Tumor immunity; Infection immunity

6631029

AAF19659.1

34,406 Da

AGE-RAGE Signaling Pathway In Diabetic Complications (1319988); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); Angiogenesis Pathway (198772); Axon Guidance Pathway (1270303); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); Cellular Response To Hypoxia Pathway (1270415); Cellular Responses To Stress Pathway (1270414); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460)

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development ().

5 x96 Tests

685 USD

5x96 Tests + MBS2090685 (Ab Pairs Support Pack 1, 5x96 Tests)

755

10x96 Tests

1080

10x96 Tests + MBS2090685 (Ab Pairs Support Pack 1, 10x96 Tests)

1195