Monoclonal Antibody to Transforming Growth Factor Beta 3 (TGFb3) | MyBioSource MBS2085915 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Monoclonal Antibody to Transforming Growth Factor Beta 3 (TGFb3)

catalog :

MBS2085915

quantity :

0.01 mg

price :

105 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[C3]

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Human MCF7 cell lysate; Primary Ab: 3ug/ml Mouse Anti-Human TGFb3 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody

image 2 :

Western Blot: Sample: Recombinant TGFb3, Human.

image 3 :

DAB staining on IHC-P; Samples: Human Lung cancer Tissue)

product information

catalog number :

MBS2085915

products type :

Antibody

products full name :

Monoclonal Antibody to Transforming Growth Factor Beta 3 (TGFb3)

products short name :

[Transforming Growth Factor Beta 3 (TGFb3)]

products name syn :

[TGF-B3; LAP; Latency-associated peptide]

other names :

[transforming growth factor beta-3 isoform 2; Transforming growth factor beta-3; transforming growth factor beta-3; transforming growth factor beta 3]

products gene name :

[TGFb3]

other gene names :

[TGFB3; TGFB3; ARVD; LDS5; RNHF; ARVD1; TGF-beta3; TGF-beta-3; LAP]

clonality :

Monoclonal

isotype :

IgG2a Kappa

clone :

[C3]

host :

Mouse

purity :

Protein A + Protein G affinity chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300,50% glycerol.

concentration :

1 mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

WB; IHC; ICC; IP.

app notes :

Western blotting: 0.5-2 Ug/mL;1:500-2000. Immunohistochemistry: 5-20 Ug/mL;1:50-200. Immunocytochemistry: 5-20 Ug/mL;1:50-200. Optimal working dilutions must be determined by end user.

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot (WB)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Organism Species: Homo sapiens (Human). Source: Monoclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant TGFb3 (Leu24~Arg300) expressed in E.coli

ncbi gi num :

1050108310

ncbi acc num :

NP_001316867.1

ncbi gb acc num :

NM_001329938.1

uniprot acc num :

P10600

ncbi pathways :

AGE-RAGE Signaling Pathway In Diabetic Complications (1319988); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); ALK1 Signaling Events Pathway (137968); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Chronic Myeloid Leukemia Pathway (83116)

ncbi summary :

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016]

uniprot summary :

TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family. Protein type: Cell development/differentiation; Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 14q24.3. Cellular Component: cell soma; cell surface; extracellular matrix; extracellular region; extracellular space; intracellular membrane-bound organelle; nucleus; plasma membrane; T-tubule. Molecular Function: cytokine activity; growth factor activity; identical protein binding; protein binding; protein heterodimerization activity; transforming growth factor beta binding; type II transforming growth factor beta receptor binding. Biological Process: activation of MAPK activity; aging; alveolus development; BMP signaling pathway; cell development; cell growth; cell-cell junction organization; embryonic neurocranium morphogenesis; female pregnancy; gut development; in utero embryonic development; inner ear development; mammary gland development; negative regulation of cell proliferation; negative regulation of DNA replication; negative regulation of neuron apoptosis; negative regulation of transforming growth factor beta receptor signaling pathway; odontogenesis; palate development; platelet degranulation; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of cell division; positive regulation of collagen biosynthetic process; positive regulation of DNA replication; positive regulation of filopodium formation; positive regulation of protein secretion; positive regulation of stress fiber formation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of apoptosis; regulation of MAPK cascade; response to estrogen; response to hypoxia; response to progesterone; salivary gland morphogenesis; transforming growth factor beta receptor signaling pathway; uterine wall breakdown; wound healing. Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome

size1 :

0.01 mg

price1 :

105 USD

size2 :

0.02 mg

price2 :

110

size3 :

0.05 mg

price3 :

145

size4 :

0.1 mg

price4 :

175

size5 :

0.2 mg

price5 :

230

size6 :

1 mg

price6 :

515

more info or order :

MyBioSource product webpage