product summary
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company name :
MyBioSource
product type :
antibody
product name :
ODC1
catalog :
MBS206623
quantity :
0.05 mL
price :
240 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
[AT9B3]
reactivity :
human
application :
western blot, ELISA, immunocytochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS206623 image 1
The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human ODC1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: 293T cell lysate Lane 1.: ODC1 transfected 293T cell lysate
image 2 :
MyBioSource MBS206623 image 2
ICC/IF analysis of ODC1 in HeLa cells. The cell was stained with ATGA0507 (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).
product information
catalog number :
MBS206623
products type :
Antibody
products full name :
ODC1
products short name :
[ODC1]
products name syn :
[Ornithine decarboxylase; ODC]
other names :
[ornithine decarboxylase isoform 1; Ornithine decarboxylase; ornithine decarboxylase; ornithine decarboxylase 1]
products gene name :
[ODC1]
other gene names :
[ODC1; ODC1; ODC; ODC]
clonality :
Monoclonal
isotype :
IgG2b, k
clone :
[AT9B3]
host :
Mouse
reactivity :
Human
sequence length :
461
purity :
By protein-A affinity chromatography
form :
Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol.
concentration :
1 mg/ml
storage stability :
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
tested application :
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
app notes :
The antibody has been tested by ELISA, Western blot analysis and ICC/IF to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
image1 heading :
Western Blot (WB)
image2 heading :
Immunofluorescence (IF)
other info1 :
Antigen Species: Human. Immunogen: Recombinant human ODC1 (1-461aa) purified from E. coli.
other info2 :
Clone Note: Anti-human ODC1 mAb, clone AT9B3, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human ODC1 protein.
products categories :
Signal Transduction
products description :
Ornithine decarboxylase, also known as ODC1, is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. ODC1 plays an important role in diverse biological processes, including cell growth, differentiation, transformation and apoptosis. Overexpression of the ODC1 gene plays important roles in cell proliferation and the development of cancer.
products references :
Moshier J A., et al. (1992) Genomics. 1:77-86. Yang Feng T L., et al. (1996) Genomics. 36:449-458.
ncbi gi num :
4505489
ncbi acc num :
NP_002530
ncbi gb acc num :
NM_002539.2
uniprot acc num :
P11926
ncbi pathways :
Amino Acid Metabolism Pathway (1471249); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Glutathione Metabolism Pathway (82973); Glutathione Metabolism Pathway (343); Integrated Breast Cancer Pathway (219801); Metabolic Pathways (132956); Metabolism Pathway (1269956); Metabolism Of Amino Acids And Derivatives Pathway (1270158); Metabolism Of Polyamines Pathway (1270170)
ncbi summary :
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]
uniprot summary :
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
size1 :
0.05 mL
price1 :
240 USD
size2 :
0.1 mL
price2 :
315
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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