protein

REN, 24-406aa, Human, His tag, Baculovirus

MBS206418

0.01 mg

310 USD

Recombinant Protein

REN, 24-406aa, Human, His tag, Baculovirus

[REN]

[Renin; REN; HNFJ2; Angiotensin forming enzyme; Angiotensin forming enzyme precursor; Angiotensinogenase; Angiotensinogenase precursor; FLJ10761; HNFJ2; REN; Ren1; RENI_HUMAN; Renin; Renin precursor renal]

[renin preproprotein; Renin; renin; renin; Angiotensinogenase]

[REN]

[REN; REN; HNFJ2]

Baculovirus

406

LPTDTTTFKR IFLKRMPSIR ESLKERGVDM ARLGPEWSQP MKRLTLGNTT SSVILTNYMD TQYYGEIGIG TPPQTFKVVF DTGSSNVWVP SSKCSRLYTA CVYHKLFDAS DSSSYKHNGT ELTLRYSTGT VSGFLSQDII TVGGITVTQM FGEVTEMPAL PFMLAEFDGV VGMGFIEQAI GRVTPIFDNI ISQGVLKEDV FSFYYNRDSE NSQSLGGQIV LGGSDPQHYE GNFHYINLIK TGVWQIQMKG VSVGSSTLLC EDGCLALVDT GASYISGSTS SIEKLMEALG AKKRLFDYVV KCNEGPTLPD ISFHLGGKEY TLTSADYVFQ ESYSSKKLCT LAIHAMDIPP PTGPTWALGA TFIRKFYTEF DRRNNRIGFA LARLEHHHHH H

> 90% by SDS-PAGE

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.

0.25mg/ml (determined by Absorbance at 280nm)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

SDS-Page

Antigen Species: Human. Tag Information: His-tag

Endotoxin Level: < 1.0 EU per 1 microgram of protein (determined by LAL method)

Cardiovascular

REN, also known as renin, is a member of the peptidase A1 family. It is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. It is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Recombinant human REN, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques

Nguyen G.,et al. (2014) Hypertension. 63:297-302.; Nabi AH.,et al. (2012) Biochem Biophys Res Commun. 428:506-511.

4506475

NP_000528

NM_000537.3

P00797

43.3kDa (391aa) 40-57kDa (SDS-PAGE under reducing conditions)

ACE Inhibitor Pathway (198763); Metabolism Of Angiotensinogen To Angiotensins Pathway (1268749); Metabolism Of Proteins Pathway (1268677); Peptide Hormone Metabolism Pathway (1268746); Renin Secretion Pathway (1222951); Renin Secretion Pathway (1238833); Renin-angiotensin System Pathway (83075); Renin-angiotensin System Pathway (486)

Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

0.01 mg

310 USD

0.05 mg

925