catalog number :
MBS206171
products type :
Recombinant Protein
products full name :
Complement component C1q receptor, 23-572aa, Mouse, His tag, Baculovirus
products short name :
[Complement component C1q receptor]
products name syn :
[Cd93; C1q/MBL/SPA receptor; C1qRp; Cell surface antigen AA4; Lymphocyte antigen 68; Ly-68]
other names :
[complement component C1q receptor; Complement component C1q receptor; complement component C1q receptor; CD93 antigen; C1q/MBL/SPA receptor; C1qR(p); C1qRp; Cell surface antigen AA4; Complement component 1 q subcomponent receptor 1; Lymphocyte antigen 68; Ly-68; CD_antigen: CD93]
products gene name :
[C1q]
other gene names :
[Cd93; Cd93; Ly68; AA4.1; C1qr1; C1qrp; AA145088; AW555904; 6030404G09Rik; Aa4; C1qr1; C1qrp; Ly68; C1qR(p); C1qRp; Ly-68]
sequence :
ADSQAVVCEG TACYTAHWGK LSAAEAQHRC NENGGNLATV KSEEEARHVQ QALTQLLKTK APLEAKMGKF WIGLQREKGN CTYHDLPMRG FSWVGGGEDT AYSNWYKASK SSCIFKRCVS LILDLSLTPH PSHLPKWHES PCGTPEAPGN SIEGFLCKFN FKGMCRPLAL GGPGRVTYTT PFQATTSSLE AVPFASVANV ACGDEAKSET HYFLCNEKTP GIFHWGSSGP LCVSPKFGCS FNNGGCQQDC FEGGDGSFRC GCRPGFRLLD DLVTCASRNP CSSNPCTGGG MCHSVPLSEN YTCRCPSGYQ LDSSQVHCVD IDECQDSPCA QDCVNTLGSF HCECWVGYQP SGPKEEACED VDECAAANSP CAQGCINTDG SFYCSCKEGY IVSGEDSTQC EDIDECSDAR GNPCDSLCFN TDGSFRCGCP PGWELAPNGV FCSRGTVFSE LPARPPQKED NDDRKESTMP PTEMPSSPSG SKDVSNRAQT TGLFVQSDIP TASVPLEIEI PSEVSDVWFE LGTYLPTTSG HSKPTHEDSV SAHSDTDGQN LEHHHHHH
purity :
> 95% by SDS-PAGE
form :
Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
concentration :
0.5 mg/ml (determined by Absorbance at 280nm)
storage stability :
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
image1 heading :
SDS-PAGE
other info1 :
Tag Information: His-tag
other info2 :
Endotoxin Level: < 1.0 EU per 1 ug of protein (determined by LAL method)
products categories :
Immunology
products description :
CD93, also known as Complement component C1q receptor, is receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). This protein mediates the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. It may play a role in intercellular adhesion. This protein was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. It is important for the maintenance of plasma cells in bone marrow niches. Recombinant mouse CD93, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
products references :
Galvan MD., et al. (2012) J. Immunol. 188 (8):3716-3723.; Greenlee-Wacker MC., et al. (2012) Curr Drug Targets 13 (3):411-420.
ncbi gb acc num :
NM_010740.3
ncbi mol weight :
60.1kDa (558aa) . 70-100KDa (SDS-PAGE under reducing conditions.)
ncbi pathways :
Immune System Pathway (1367472); Innate Immune System Pathway (1367502); Neutrophil Degranulation Pathway (1457939)
uniprot summary :
Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion. Marker for early multipotent hematopoietic precursor cells. May play a role in cell-cell interactions during hematopoietic and vascular development.