protein

PAX8, 1-287aa, Human, His tag, E Coli

MBS206102

0.05 mg

375 USD

Recombinant Protein

PAX8, 1-287aa, Human, His tag, E Coli

[PAX8]

[Paired box protein Pax-8 isoform PAX8E; Paired box protein Pax-8 isoform PAX8E; paired box 8]

[paired box protein Pax-8 isoform PAX8E; Paired box protein Pax-8; paired box protein Pax-8; paired box 8]

[PAX8]

[PAX8; PAX8]

E Coli

[1-287]

287

MGSSHHHHHH SSGLVPRGSH MGSMPHNSIR SGHGGLNQLG GAFVNGRPLP EVVRQRIVDL AHQGVRPCDI SRQLRVSHGC VSKILGRYYE TGSIRPGVIG GSKPKVATPK VVEKIGDYKR QNPTMFAWEI RDRLLAEGVC DNDTVPSVSS INRIIRTKVQ QPFNLPMDSC VATKSLSPGH TLIPSSAVTP PESPQSDSLG STYSINGLLG IAQPGSDKRK MDDSDQDSCR LSIDSQSSSS GPRKHLRTDA FSQHHLEPLE CPFERQHYPE AYASPSHTKG EQEVNTLAMP MATPPTPPTA RPGASPTPAC

> 90% by SDS-PAGE

Liquid. In phosphate buffer saline (pH 7.4) containing 20% glycerol, 1mM DTT

0.25 mg/ml (determined by Bradford assay)

Can be stored at 2-8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

SDS-Page

Antigen Species: Human. Tag Information: His-tag

Neuroscience

Paired box protein Pax-8 isoform PAX8E, also known as PAX8, is expressed in the developing and adult thyroid, the developing secretory system and at lower levels, in the adult kidney. PAX8complexes with TTF-1 and TTF-2 to induce thyroid follicular cell differentiation and thyroid hormone biosynthesis by regulating the expression of sodium iodide symporter (NIS), thyroid peroxidase (TPO), thyroglobulin (TG) and the thyrotropin receptor (TSHR). Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2). Recombinant human PAX8 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

Paters H., et al. (1998) Eur J Oral Sci. 106: 38-43.; Poleev A., et al. (1995) Eur J Biochem. 228: 899-911.;

7669542

NP_054698

NM_013992.3

Q06710

33.4 kDa (310aa) confirmed by MALDI-TOF

Human Thyroid Stimulating Hormone (TSH) Signaling Pathway (672446); ID Signaling Pathway (198871); Pathways In Cancer (83105); Thyroid Cancer Pathway (83112); Thyroid Cancer Pathway (524); Thyroid Hormone Synthesis Pathway (835410); Thyroid Hormone Synthesis Pathway (839541); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]

Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.

0.05 mg

375 USD

0.25 mg

925