CADM1, 45-374aa, Human, His tag, E Coli | MyBioSource MBS206025 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

CADM1, 45-374aa, Human, His tag, E Coli

catalog :

MBS206025

quantity :

0.02 mg

price :

310 USD

more info or order :

MyBioSource product webpage

image

image 1 :

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain

product information

catalog number :

MBS206025

products type :

Recombinant Protein

products full name :

CADM1, 45-374aa, Human, His tag, E Coli

products short name :

[CADM1]

products name syn :

[Cell adhesion molecule 1; BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175; sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1]

other names :

[cell adhesion molecule 1 isoform D; Cell adhesion molecule 1; cell adhesion molecule 1; cell adhesion molecule 1; Immunoglobulin superfamily member 4; IgSF4; Nectin-like protein 2; NECL-2; Spermatogenic immunoglobulin superfamily; SgIgSF; Synaptic cell adhesion molecule; SynCAM; Tumor suppressor in lung cancer 1; TSLC-1]

products gene name :

[CADM1]

other gene names :

[CADM1; CADM1; BL2; ST17; IGSF4; NECL2; RA175; TSLC1; IGSF4A; Necl-2; SYNCAM; sgIGSF; sTSLC-1; synCAM1; IgSF4; NECL-2; SgIgSF; SynCAM; TSLC-1]

host :

E Coli

sequence positions :

[45-374aa]

sequence length :

442

sequence :

MGSSHHHHHH SSGLVPRGSH MGSQNLFTKD VTVIEGEVAT ISCQVNKSDD SVIQLLNPNR QTIYFRDFRP LKDSRFQLLN FSSSELKVSL TNVSISDEGR YFCQLYTDPP QESYTTITVL VPPRNLMIDI QKDTAVEGEE IEVNCTAMAS KPATTIRWFK GNTELKGKSE VEEWSDMYTV TSQLMLKVHK EDDGVPVICQ VEHPAVTGNL QTQRYLEVQY KPQVHIQMTY PLQGLTREGD ALELTCEAIG KPQPVMVTWV RVDDEMPQHA VLSGPNLFIN NLNKTDNGTY RCEASNIVGK AHSDYMLYVY DPPTTIPPPT TTTTTTTTTT TTILTIITDS RAGEEGSIRA VDH

purity :

> 85% by SDS-PAGE

form :

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol, 1mM DTT

concentration :

0.25 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

image1 heading :

SDS-Page

other info1 :

Tag: His-tag

products categories :

Neuroscience

products description :

CADM1 mediates homophilic cell-cell adhesion in a Ca2+-independent manner and also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. This protein acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Recombinant human CADM1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

products references :

Barton C.H., et al. (1988) Development 104:165-173.

ncbi gi num :

148664190

ncbi acc num :

NP_055148

ncbi gb acc num :

NM_014333.3

uniprot acc num :

Q9BY67

ncbi mol weight :

39.4 kDa (353aa) confirmed by MALDI-TOF

ncbi pathways :

Adherens Junctions Interactions Pathway (1270234); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (1270232); Cell-Cell Communication Pathway (1270231); Cell-cell Junction Organization Pathway (1270233); Nectin/Necl Trans Heterodimerization Pathway (1270235)

uniprot summary :

Mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca2+-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

size1 :

0.02 mg

price1 :

310 USD

size2 :

0.1 mg

price2 :

720

more info or order :

MyBioSource product webpage