YBX1, 1-324aa, Human, His tag, E Coli | MyBioSource MBS206015 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

YBX1, 1-324aa, Human, His tag, E Coli

catalog :

MBS206015

quantity :

0.1 mg

price :

310 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS206015

products type :

Recombinant Protein

products full name :

YBX1, 1-324aa, Human, His tag, E Coli

products short name :

[YBX1]

products name syn :

[Nuclease-sensitive element-binding protein 1; BP-8; CSDA2; CSDB; DBPB; MDR-NF1; NSEP-1; NSEP1; YB-1; YB1]

other names :

[nuclease-sensitive element-binding protein 1; Nuclease-sensitive element-binding protein 1; nuclease-sensitive element-binding protein 1; Y-box binding protein 1; CCAAT-binding transcription factor I subunit A; CBF-A; DNA-binding protein B; DBPB; Enhancer factor I subunit A; EFI-A; Y-box transcription factor; Y-box-binding protein 1; YB-1]

products gene name :

[YBX1]

other gene names :

[YBX1; YBX1; YB1; BP-8; CSDB; DBPB; YB-1; CBF-A; CSDA2; EFI-A; NSEP1; NSEP-1; MDR-NF1; NSEP1; YB1; CBF-A; DBPB; EFI-A; YB-1]

host :

E Coli

sequence length :

1-324aa

purity :

> 85% by SDS-PAGE

form :

Liquid. Phosphate buffered saline (pH 7.4) containing 20% glycerol

concentration :

0.5 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 2-8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

image1 heading :

SDS-Page

other info1 :

Tag Information: His-tag

products categories :

Epigenomics (Transcription & Translation)

products description :

YBX1, also known as Y box binding protein 1, associates with the selenocysteine insertion sequence and functions in mammalian selenoprotein translation. This protein is a potential drug target in cancer therapy. It helps the replication of adenovirus type 5, a commonly used vector in gene therapy. Thus, YBX1 can cause an oncolytic effect in YBX1 positive cancer cells treated with adenoviruses. Recombinant human YBX1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.

products references :

Shen Q. et al. (2006) J Cell Physiol. 207:775-783.; Chernukhin IV. et al. (2000) J Biol Chem. 275:29915-29921

ncbi gi num :

34098946

ncbi acc num :

NP_004550

ncbi gb acc num :

NM_004559.4

uniprot acc num :

P67809

ncbi mol weight :

38.3 kDa (347aa) confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)

ncbi pathways :

Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway (712093); Gene Expression Pathway (1269649); MECP2 And Associated Rett Syndrome Pathway (1458229); Processing Of Capped Intron-Containing Pre-mRNA Pathway (1269688); Signaling Events Mediated By PTP1B Pathway (138017); Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways (198901); MRNA Processing Pathway (198843); MRNA Splicing Pathway (1269689); MRNA Splicing - Major Pathway (1269690); MRNA Splicing - Minor Pathway (1269691)

ncbi summary :

This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015]

uniprot summary :

Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro.

size1 :

0.1 mg

price1 :

310 USD

size2 :

0.5 mg

price2 :

720

more info or order :

MyBioSource product webpage