APC-Linked Polyclonal Antibody to Transglutaminase 2, Tissue (TGM2) | MyBioSource MBS2059642 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

APC-Linked Polyclonal Antibody to Transglutaminase 2, Tissue (TGM2)

catalog :

MBS2059642

quantity :

0.1 mg

price :

295 USD

clonality :

polyclonal

host :

rabbit

conjugate :

APC

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Knockout Validation: Lane 1: Wild-type Hela cell lysate; Lane 2: TGM2 knockout Hela cell lysate; Predicted MW: 77kd Observed MW: 77kd Primary Ab: 1ug/ml Rabbit Anti-Human TGM2 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047)

product information

catalog number :

MBS2059642

products type :

Antibody

products full name :

APC-Linked Polyclonal Antibody to Transglutaminase 2, Tissue (TGM2)

products short name :

[Transglutaminase 2 (TGM2)]

products name syn :

[tTG; TG2; C Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase; Transglutaminase C; Transglutaminase H]

other names :

[transglutaminase 2; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine gamma-glutamyltransferase 2; transglutaminase 2; Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2]

products gene name :

[TGM2]

other gene names :

[TGM2; TGM2; TGC; TG(C); TG(C); TGC; TGase C; TGase H; TGase-2]

clonality :

Polyclonal

host :

Rabbit

purity :

Antigen-specific Affinity Chromatography.

form :

Supplied as solution form 0.02% NaN 3 , 10 mM Tris, 150 mM NaCI, pH 8.2, 50% glycerol 0.02% NaN 3

concentration :

0.34 mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Western Blot (WB); Immunocytochemistry (IHC); Immunocytochemistry (ICC); Immunoprecipitation (IP).

app notes :

Western blotting: 0.5-2 ug/mL;1:170-680. Immunohistochemistry: 5-20 ug/mL;1:17-68. Immunocytochemistry: 5-20 ug/mL;1:17-68. Optimal working dilutions must be determined by end user

image1 heading :

Knockout Validation

other info1 :

Organism Species: Homo sapiens (Human). Source: Antibody labeling. Label: APC. Traits: Liquid. Immunogen: Recombinant TGM2 (Met1~Ala687) expressed in E.coli.

ncbi gi num :

50593093

ncbi acc num :

AAT79353.1

ncbi pathways :

Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Thromboxane A2 Receptor Signaling Pathway (138060)

ncbi summary :

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

TGM2: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described. Protein type: EC 2.3.2.13; Transferase. Chromosomal Location of Human Ortholog: 20q11.23. Cellular Component: cytosol; extracellular matrix; focal adhesion; intrinsic to plasma membrane; mitochondrion. Molecular Function: protein binding; protein-glutamine gamma-glutamyltransferase activity. Biological Process: apoptotic cell clearance; elevation of mitochondrial calcium ion concentration; positive regulation of apoptosis; positive regulation of cell adhesion; reduction of endoplasmic reticulum calcium ion concentration

size1 :

0.1 mg

price1 :

295 USD

size2 :

0.2 mg

price2 :

470

size3 :

1 mg

price3 :

1120

more info or order :

MyBioSource product webpage