protein

EREG, 63-108aa, Human, His tag, E Coli

MBS205963

0.1 mg

310 USD

Recombinant Protein

EREG, 63-108aa, Human, His tag, E Coli

EREG

Proepiregulin; ER

proepiregulin preproprotein; Proepiregulin; proepiregulin; epiregulin

EREG

EREG; EREG; ER; EPR

EREG_HUMAN

169

MGSSHHHHHH SSGLVPRGSH MGSVSITKCS SDMNGYCLHG QCIYLVDMSQ NYCRCEVGYT GVRCEHFFL

> 80% by SDS - PAGE

Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol

0.5 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Hormones & Cytokines

EREG, also known as epiregulin, is a member of the epidermal growth factor family. It can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. It may be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis. Recombinant human EREG protein, fused to His-tag at N-terminus, was expressed in E.coli.

Yun J. et al. (2012) Lab Invest. 92:1033-1044. Thuong NT. et al. (2012) Genes Immun. 13:275-281.

4557567

NP_001423

NM_001432.2

7.7 kDa(69aa)

Adaptive Immune System Pathway (366160); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764); Downstream Signal Transduction Pathway (106385); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (576250); Downstream Signaling Of Activated FGFR Pathway (160957); ErbB Receptor Signaling Network Pathway (138016); ErbB Signaling Pathway (198844)

Epiregulin is a member of the epidermal growth factor family. Epiregulin can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. [provided by RefSeq, Jul 2008]

Epiregulin: Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 4q13.3. Cellular Component: extracellular space; integral to plasma membrane; extracellular region. Molecular Function: protein binding; growth factor activity; epidermal growth factor receptor binding. Biological Process: response to peptide hormone stimulus; wound healing; nerve growth factor receptor signaling pathway; activation of MAPK activity; positive regulation of interleukin-6 biosynthetic process; positive regulation of smooth muscle cell proliferation; female meiosis; negative regulation of smooth muscle cell differentiation; negative regulation of cell proliferation; positive regulation of fibroblast proliferation; primary follicle stage, oogenesis; positive regulation of epidermal growth factor receptor activity; cell-cell signaling; positive regulation of cell proliferation; positive regulation of innate immune response; ovarian cumulus expansion; angiogenesis; negative regulation of epithelial cell proliferation; epidermal growth factor receptor signaling pathway; positive regulation of cytokine production; anatomical structure morphogenesis; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of mitosis; cytokine and chemokine mediated signaling pathway; positive regulation of cytokine biosynthetic process; keratinocyte proliferation; luteinizing hormone signaling pathway; oocyte maturation; keratinocyte differentiation; ovulation; organ morphogenesis; positive regulation of protein kinase activity; mRNA transcription; innate immune response; negative regulation of transcription, DNA-dependent; positive regulation of phosphorylation; positive regulation of DNA replication

0.1 mg

310 USD

0.5 mg

720