product summary
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company name :
MyBioSource
product type :
protein
product name :
NRF2, 1-605aa, Human, His tag, E Coli
catalog :
MBS205893
quantity :
0.02 mg
price :
310 USD
more info or order :
image
image 1 :
3 ug by SDS-PAGE under reducing condition and visualized by coomasie blue stain
product information
catalog number :
MBS205893
products type :
Recombinant Protein
products full name :
NRF2, 1-605aa, Human, His tag, E Coli
products short name :
[NRF2]
products name syn :
[Nuclear factor (erythroid-derived 2)-like 2; Nuclear factor (erythroid-derived 2)-like 2; NFE2L2]
other names :
[guanine nucleotide exchange factor for Rab-3A isoform 1; Guanine nucleotide exchange factor for Rab-3A; guanine nucleotide exchange factor for Rab-3A; RAB3A interacting protein like 1; Rab-3A-interacting-like protein 1; Rab3A-interacting-like protein 1; Rabin3-like 1]
products gene name :
[NRF2]
other gene names :
[RAB3IL1; RAB3IL1; GRAB; Rab3A-interacting-like protein 1]
host :
E Coli
sequence positions :
[1-605aa]
sequence length :
382
sequence :
MGSSHHHHHH SSGLVPRGSH MMDLELPPPG LPSQQDMDLI DILWRQDIDL GVSREVFDFS QRRKEYELEK QKKLEKERQE QLQKEQEKAF FAQLQLDEET GEFLPIQPAQ HIQSETSGSA NYSQVAHIPK SDALYFDDCM QLLAQTFPFV DDNEVSSATF QSLVPDIPGH IESPVFIATN QAQSPETSVA QVAPVDLDGM QQDIEQVWEE LLSIPELQCL NIENDKLVET TMVPSPEAKL TEVDNYHFYS SIPSMEKEVG NCSPHFLNAF EDSFSSILST EDPNQLTVNS LNSDATVNTD FGDEFYSAFI AEPSISNSMP SPATLSHSLS ELLNGPIDVS DLSLCKAFNQ NHPESTAEFN DSDSGISLNT SPSVASPEHS VESSSYGDTL LGLSDSEVEE LDSAPGSVKQ NGPKTPVHSS GDMVQPLSPS QGQSTHVHDA QCENTPEKEL PVSPGHRKTP FTKDKHSSRL EAHLTRDELR AKALHIPFPV EKIINLPVVD FNEMMSKEQF NEAQLALIRD IRRRGKNKVA AQNCRKRKLE NIVELEQDLD HLKDEKEKLL KEKGENDKSL HLLKKQLSTL YLEVFSMLRD EDGKPYSPSE YSLQQTRDGN VFLVPKSKKP DVKKN
purity :
> 85% by SDS-PAGE
form :
Liquid. In phosphate buffer saline (pH 7.4) containing 10% glycerol
concentration :
0.25 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 2-8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles .
tested application :
SDS-PAGE
image1 heading :
SDS-Page
other info1 :
Tag Information: His-tag
products categories :
Epigenetics
products description :
Nuclear factor (erythroid-derived 2)-like 2, also known as NRF2, is bZIP transcription factors that heterodimerize with Maf proteins to bind Mare sequences. The NRF proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. NRF2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from its repressor protein, Keap1. Recombinant human NRF2 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
products references :
Huang H C., et al. (2000) Proc Natl Acad Sci uSA. 97: 12475-12480.; Tsai P Y., et al. (2012) Arthritis Rheum. 64: 232-242.;
ncbi gi num :
21361440
ncbi acc num :
NP_006155
ncbi gb acc num :
NM_013401.3
uniprot acc num :
Q8TBN0
ncbi mol weight :
69.9kDa (625aa)
ncbi pathways :
Membrane Trafficking Pathway (1269877); RAB GEFs Exchange GTP For GDP On RABs Pathway (1457806); Vesicle-mediated Transport Pathway (1269876)
ncbi summary :
This gene encodes a guanine nucleotide exchange factor for the ras-related protein Rab3A. The encoded protein binds Rab3a and the inositol hexakisphosphate kinase InsP6K1. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2012]
uniprot summary :
Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B.
size1 :
0.02 mg
price1 :
310 USD
size2 :
0.1 mg
price2 :
720
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
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