protein

KRT17, 1-432aa, Human, His tag, E Coli (Denatured)

MBS205760

0.1 mg

375 USD

Recombinant Protein

KRT17, 1-432aa, Human, His tag, E Coli (Denatured)

[KRT17]

[Keratin type I cytoskeletal 17; Keratin; type I cytoskeletal 17; K17; PC; PC2; PCHC1]

[keratin, type I cytoskeletal 17; Keratin, type I cytoskeletal 17; keratin, type I cytoskeletal 17; keratin 17; 39.1; Cytokeratin-17; CK-17; Keratin-17; K17]

[KRT17]

[KRT17; KRT17; PC; K17; PC2; 39.1; CK-17; PCHC1; CK-17; K17]

E Coli

432

MGSSHHHHHH SSGLVPRGSH MGSMTTSIRQ FTSSSSIKGS SGLGGGSSRT SCRLSGGLGA GSCRLGSAGG LGSTLGGSSY SSCYSFGSGG GYGSSFGGVD GLLAGGEKAT MQNLNDRLAS YLDKVRALEE ANTELEVKIR DWYQRQAPGP ARDYSQYYRT IEELQNKILT ATVDNANILL QIDNARLAAD DFRTKFETEQ ALRLSVEADI NGLRRVLDEL TLARADLEMQ IENLKEELAY LKKNHEEEMN ALRGQVGGEI NVEMDAAPGV DLSRILNEMR DQYEKMAEKN RKDAEDWFFS KTEELNREVA TNSELVQSGK SEISELRRTM QALEIELQSQ LSMKASLEGN LAETENRYCV QLSQIQGLIG SVEEQLAQLR CEMEQQNQEY KILLDVKTRL EQEIATYRRL LEGEDAHLTQ YKKEPVTTRQ VRTIVEEVQD GKVISSREQV HQTTR

> 90% by SDS-PAGE

Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol 0.4M urea

0.5 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

SDS-Page

Antigen Species: Human. Tag Information: His-tag

Signal Transduction

KRT17, as known as keratin17, is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in KRT17 lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. Recombinant human KRT17 protein, fused to His-tag at N-terminus, was expressed in E Coli.

McLean WH. et al. (1995) Nat Genet. 9:273-278.; Troyanovsky SM. et al. (1993) Eur J Cell Biol. 59: 127-137.;

4557701

NP_000413

NM_000422.2

Q04695

50.5 kDa (455aa)

Developmental Biology Pathway (1270302); Glucocorticoid Receptor Regulatory Network Pathway (138014); Keratinization Pathway (1457790)

This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

0.1 mg

375 USD

0.5 mg

925