F2, 328-622aa, Human, E Coli (Denatured) | MyBioSource MBS205719 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

F2, 328-622aa, Human, E Coli (Denatured)

catalog :

MBS205719

quantity :

0.1 mg

price :

310 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS205719

products type :

Recombinant Protein

products full name :

F2, 328-622aa, Human, E Coli (Denatured)

products short name :

[F2]

products name syn :

[Coagulation factor II; Factor II (thrombin); PT]

other names :

[prothrombin isoform 1 preproprotein; Prothrombin; prothrombin; coagulation factor II, thrombin; Coagulation factor II]

products gene name :

[F2]

other gene names :

[F2; F2; PT; THPH1; RPRGL2]

host :

E Coli

sequence length :

622

sequence :

MTFGSGEADC GLRPLFEKKS LEDKTERELL ESYIDGRIVE GSDAEIGMSP WQVMLFRKSP QELLCGASLI SDRWVLTAAH CLLYPPWDKN FTENDLLVRI GKHSRTRYER NIEKISMLEK IYIHPRYNWR ENLDRDIALM KLKKPVAFSD YIHPVCLPDR ETAASLLQAG YKGRVTGWGN LKETWTANVG KGQPSVLQVV NLPIVERPVC KDSTRIRITD NMFCAGYKPD EGKRGDACEG DSGGPFVMKS PFNNRWYQMG IVSWGEGCDR DGKYGFYTHV FRLKKWIQKV IDQFGE

purity :

> 80% by SDS-PAGE

form :

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol.

concentration :

1.0 mg/ml (determined by Bradford assay)

storage stability :

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

tested application :

SDS-PAGE

image1 heading :

SDS-Page

other info1 :

Antigen Species: Human. Tag Information: His-tag

products categories :

Apoptosis

products description :

Coagulation factor II, also known as F2, is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Recombinant human F2 protein was expressed in E Coli.

products references :

Royle NJ, Irwin DM, Koschinsky ML., et al. (1987) Somat. Cell Mol. Genet. 13 (3): 285-92

ncbi gi num :

4503635

ncbi acc num :

NP_000497

ncbi gb acc num :

NM_000506.4

uniprot acc num :

P00734

ncbi mol weight :

33.9kDa (296aa)

ncbi pathways :

Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Blood Clotting Cascade Pathway (198840); Cell Surface Interactions At The Vascular Wall Pathway (1269373); Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); Common Pathway Of Fibrin Clot Formation (1269371); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Folate Metabolism Pathway (198833)

ncbi summary :

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

uniprot summary :

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

size1 :

0.1 mg

price1 :

310 USD

size2 :

0.5 mg

price2 :

720

more info or order :

MyBioSource product webpage

company information

MyBioSource

P.O. Box 153308
San Diego, CA 92195-3308

sales@mybiosource.com

https://www.mybiosource.com

1-888-627-0165

headquarters: USA

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