Cy3-Linked Polyclonal Antibody to Interleukin 2 Receptor Gamma (IL2Rg) | MyBioSource MBS2056087 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Cy3-Linked Polyclonal Antibody to Interleukin 2 Receptor Gamma (IL2Rg)

catalog :

MBS2056087

quantity :

0.1 mg

price :

395 USD

clonality :

polyclonal

host :

rabbit

conjugate :

Cy3

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2056087

products type :

Antibody

products full name :

Cy3-Linked Polyclonal Antibody to Interleukin 2 Receptor Gamma (IL2Rg)

products short name :

[Interleukin 2 Receptor Gamma (IL2Rg)]

products name syn :

[CD132; IL2R-g; IL2-RG; CD132; IMD4; p64; SCIDX; SCIDX1; Cytokine Receptor Common Gamma Chain; Severe Combined Immunodeficiency]

other names :

[interleukin 2 receptor gamma chain; Cytokine receptor common subunit gamma; cytokine receptor common subunit gamma; interleukin 2 receptor subunit gamma; Interleukin-2 receptor subunit gamma; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; gammaC; p64; CD_antigen: CD132]

products gene name :

[IL2Rg]

other gene names :

[IL2RG; IL2RG; P64; CIDX; IMD4; CD132; SCIDX; IL-2RG; SCIDX1; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG]

clonality :

Polyclonal

host :

Rabbit

purity :

Antigen-specific Affinity Chromatography

form :

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

concentration :

0.63 mg/mL

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition. Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.

tested application :

WB; IHC; ICC; IF.

app notes :

Western blotting: 0.5-2 ug/mL;1:320-1250. Immunohistochemistry: 5-20 ug/mL;1:32-125. Immunocytochemistry: 5-20 ug/mL;1:32-125. Optimal working dilutions must be determined by end user.

other info1 :

Organism Species: Homo sapiens (Human). Source: Antibody labeling. Label: Cy3. Traits: Liquid. Immunogen: Recombinant IL2Rg (Leu23~Ala262) expressed in E.coli.

other info2 :

Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2005897

ncbi gi num :

307058

ncbi acc num :

AAA59145.1

ncbi pathways :

Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); Endocytosis Pathway (102279); Endocytosis Pathway (102181); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); IL-2 Signaling Pathway (198885); IL-4 Signaling Pathway (198760)

ncbi summary :

The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]

uniprot summary :

IL2RG: Common subunit for the receptors for a variety of interleukins. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell- negative (XSCID); also known as agammaglobulinemia Swiss type. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell- mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Defects in IL2RG are the cause of X-linked combined immunodeficiency (XCID). XCID is a less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID. Belongs to the type I cytokine receptor family. Type 5 subfamily. Protein type: Membrane protein, integral; Receptor, cytokine. Chromosomal Location of Human Ortholog: Xq13.1. Cellular Component: external side of plasma membrane; integral to plasma membrane; membrane; plasma membrane. Molecular Function: interleukin-2 binding; interleukin-2 receptor activity; interleukin-4 receptor activity; interleukin-7 receptor activity; protein binding; Ras guanyl-nucleotide exchange factor activity. Biological Process: immune response; MAPKKK cascade. Disease: Combined Immunodeficiency, X-linked; Severe Combined Immunodeficiency, X-linked

size1 :

0.1 mg

price1 :

395 USD

size2 :

0.2 mg

price2 :

615

size3 :

1 mg

price3 :

1490

more info or order :

MyBioSource product webpage