product summary
Loading...
company name :
MyBioSource
product type :
protein
product name :
HOXA9, 1-272aa, Human, His tag, E Coli
catalog :
MBS205604
quantity :
0.1 mg
price :
310 USD
more info or order :
product information
catalog number :
MBS205604
products type :
Recombinant Protein
products full name :
HOXA9, 1-272aa, Human, His tag, E Coli
products short name :
HOXA9
products name syn :
Homeobox protein Hox-A9; ABD-B; HOX1; HOX1.7; HOX1
other names :
homeobox protein Hox-A9; Homeobox protein Hox-A9; homeobox protein Hox-A9; homeobox protein Hox-1G; homeodomain protein HOXA9; homeobox A9; Homeobox protein Hox-1G
products gene name :
HOXA9
other gene names :
HOXA9; HOXA9; HOX1; ABD-B; HOX1G; HOX1.7; HOX1G
uniprot entry name :
HXA9_HUMAN
sequence length :
272
sequence :
MGSSHHHHHH SSGLVPRGSH MGSMATTGAL GNYYVDSFLL GADAADELSV GRYAPGTLGQ PPRQAATLAE HPDFSPCSFQ SKATVFGASW NPVHAAGANA VPAAVYHHHH HHPYVHPQAP VAAAAPDGRY MRSWLEPTPG ALSFAGLPSS RPYGIKPEPL SARRGDCPTL DTHTLSLTDY ACGSPPVDRE KQPSEGAFSE NNAENESGGD KPPIDPNNPA ANWLHARSTR KKRCPYTKHQ TLELEKEFLF NMYLTRDRRY EVARLLNLTE RQVKIWFQNR RMKMKKINKD RAKDE
purity :
> 85% by SDS - PAGE
form :
Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Stem Cell
products description :
HOXA9 belongs to the Abd-B homeobox family. This protein is a transcription factor with a central role in both haemopoiesis and leukaemia. High levels of HOXA9 expression in haemopoietic cells is a characteristic feature of acute myeloid leukaemia (AML), and may be sufficient to cause this disease. Overexpression of Hoxa 9 markedly expands hematopoietic stem cells. Recombinant human HOXA9 protein, fused to His-tag at N-terminus, was expressed in E.coli.
products references :
Bandyopadhyay S., et al. (2012) Mol. Cell. Biol. 32:1202-1213. Patel C.V., et al. (1999) J. Biol. Chem. 274:1415-1422.
ncbi gi num :
23097236
ncbi acc num :
NP_689952
ncbi gb acc num :
NM_152739.3
ncbi mol weight :
32.6 kDa (295aa)
ncbi pathways :
TGF-beta Receptor Signaling Pathway (198774); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)
ncbi summary :
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]
uniprot summary :
HOXA9: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98. A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2. Belongs to the Abd-B homeobox family. Protein type: Oncoprotein; DNA-binding. Chromosomal Location of Human Ortholog: 7p15.2. Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus. Molecular Function: protein binding; enzyme binding; sequence-specific DNA binding. Biological Process: embryonic forelimb morphogenesis; negative regulation of myeloid cell differentiation; transcription, DNA-dependent; multicellular organismal development; embryonic skeletal development; male gonad development; uterus development; endothelial cell activation; anterior/posterior pattern formation; mammary gland development; regulation of transcription, DNA-dependent; single fertilization; spermatogenesis; proximal/distal pattern formation
size1 :
0.1 mg
price1 :
310 USD
size2 :
0.5 mg
price2 :
720
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!