protein

MMP8, 101- 467aa, Human, His tag, E Coli (Denatured)

MBS205583

0.1 mg

310 USD

Recombinant Protein

MMP8, 101- 467aa, Human, His tag, E Coli (Denatured)

[MMP8]

[neutrophil collagenase preproprotein; CLG1; HNC; MMP-8; PMNL-CL]

[neutrophil collagenase isoform 1 preproprotein; Neutrophil collagenase; neutrophil collagenase; matrix metallopeptidase 8; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL]

[MMP8]

[MMP8; MMP8; HNC; CLG1; MMP-8; PMNL-CL; CLG1; MMP-8; PMNL-CL]

E Coli

467

MGSSHHHHHH SSGLVPRGSH MGSLTPGNPK WERTNLTYRI RNYTPQLSEA EVERAIKDAF ELWSVASPLI FTRISQGEAD INIAFYQRDH GDNSPFDGPN GILAHAFQPG QGIGGDAHFD AEETWTNTSA NYNLFLVAAH EFGHSLGLAH SSDPGALMYP NYAFRETSNY SLPQDDIDGI QAIYGLSSNP IQPTGPSTPK PCDPSLTFDA ITTLRGEILF FKDRYFWRRH PQLQRVEMNF ISLFWPSLPT GIQAAYEDFD RDLIFLFKGN QYWALSGYDI LQGYPKDISN YGFPSSVQAI DAAVFYRSKT YFFVNDQFWR YDNQRQFMEP GYPKSISGAF PGIESKVDAV FQQEHFFHVF SGPRYYAFDL IAQRVTRVAR GNKWLNCRYG

> 85% by SDS-PAGE

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 0.4M urea

1mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

SDS-Page

Antigen Species: Human. Tag Information: His-tag

Cancer

MMP8 protein of the matrix metalloproteinase (MMP) family is involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. MMP8 is part of a cluster of MMP. Recombinant human MMP8 protein, fused to His-tag at N-terminus, was expressed in E Coli.

Hasty K.A., et al (1990). J. Biol. Chem. 265:11421-11424; Betz M., et al (1997). Eur. J. Biochem. 247:356-363;

4505221

NP_002415

NM_002424.2

P22894

44.3 kDa (390aa)

Activation Of Matrix Metalloproteinases Pathway (1270258); Collagen Degradation Pathway (1270259); Degradation Of The Extracellular Matrix Pathway (1270257); Extracellular Matrix Organization Pathway (1270244); Immune System Pathway (1269170); Innate Immune System Pathway (1269203); Matrix Metalloproteinases Pathway (198900); Neutrophil Degranulation Pathway (1457780)

This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Can degrade fibrillar type I, II, and III collagens.

0.1 mg

310 USD

0.5 mg

720