antibody

HRP-Linked Polyclonal Antibody to Mannose Binding Lectin (MBL)

MBS2055691

0.1 mg

270 USD

polyclonal

rabbit

HRP

western blot, immunohistochemistry, immunocytochemistry

Antibody

HRP-Linked Polyclonal Antibody to Mannose Binding Lectin (MBL)

[Mannose Binding Lectin (MBL)]

[MBL2; COLEC1; HSMBPC; MBP1; MBP; Collectin-1; Mannose-binding protein C; Mannan Binding Protein; Mannose-Binding Lectin (Protein C)2, Soluble (Opsonic Defect)]

[mannose binding lectin, partial; Mannose-binding protein C; mannose-binding protein C; mannose binding lectin 2; Collectin-1; MBP1; Mannan-binding protein; Mannose-binding lectin]

[MBL]

[MBL2; MBL2; MBL; MBP; MBP1; MBPD; MBL2D; MBP-C; COLEC1; HSMBPC; COLEC1; MBL; MBP-C]

Polyclonal

Rabbit

Antigen-specific Affinity Chromatography.

Supplied as solution form in PBS, pH7.4, 50% glycerol 0.05% Proclin-300.

0.73mg/ml

Storage: Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 24 months. Stability Test:. The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunofluorescence (IF)

Western blotting: 0.5-2ug/mL;. Immunohistochemistry: 5-20ug/mL;. Immunocytochemistry: 5-20ug/mL;. Optimal working dilutions must be determined by end user.

Organism Species: Homo sapiens (Human). Source: Antibody labeling. Label: HRP. Traits: Liquid. Immunogen: Recombinant MBL (Lys129~Asp244) expressed in E.coli.

189503722

ACE06983.1

Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (1269241); Creation Of C4 And C2 Activators Pathway (1269243); Immune System Pathway (1269170); Initial Triggering Of Complement Pathway (1269242); Innate Immune System Pathway (1269203); Lectin Pathway Of Complement Activation (1269244); Phagosome Pathway (153910); Phagosome Pathway (153859)

This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008]

MBL2: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 10q21.1. Cellular Component: cell surface; extracellular region; extracellular space. Molecular Function: calcium ion binding; calcium-dependent protein binding; mannose binding; protein binding; receptor binding; serine-type endopeptidase activity. Biological Process: acute-phase response; complement activation; complement activation, lectin pathway; defense response to bacterium; defense response to Gram-positive bacterium; innate immune response; negative regulation of viral reproduction; opsonization. Disease: Mannose-binding Protein Deficiency

0.1 mg

270 USD

0.2 mg

425

1 mg

1005