catalog number :
MBS2055155
products full name :
FITC-Linked Polyclonal Antibody to Proteinase 3 (PR3)
products short name :
[Proteinase 3 (PR3)]
products name syn :
[MBN; PRTN3; ACPA; AGP7; C-ANCA; MBT; P29; PRK; Myeloblastin; Serine Proteinase, Neutrophil, Wegener Granulomatosis Autoantigen; Protease K; Proteinase K; Endopeptidase K]
other names :
[proteinase 3; Myeloblastin; myeloblastin; proteinase 3; AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen]
products gene name :
[PR3]
other gene names :
[PRTN3; PRTN3; MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA; MBN; PR-3; PR3; NP-4]
purity :
Antigen-specific Affinity Chromatography
form :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
concentration :
0.36 mg/ml
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition. Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.
tested application :
WB, IHC, ICC, IP
app notes :
Western blotting: 0.5-2 ug/mL;1:180-700. Immunohistochemistry: 5-20 ug/mL;1:18-70. Immunocytochemistry: 5-20 ug/mL;1:18-70. Optimal working dilutions must be determined by end user.
other info1 :
Immunogen: PR3 (Ala24~Leu249). Conjugation: FITC
other info2 :
Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2005777
ncbi acc num :
CAA39203.1
ncbi pathways :
C-MYB Transcription Factor Network Pathway (138073); Common Pathway (106060); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Hemostasis Pathway (106028)
uniprot summary :
PRTN3: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. Belongs to the peptidase S1 family. Elastase subfamily. Protein type: Cell cycle regulation; EC 3.4.21.76; Protease. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: cytosol; extracellular matrix; extracellular space; plasma membrane. Molecular Function: enzyme binding; serine-type endopeptidase activity; serine-type peptidase activity. Biological Process: blood coagulation; negative regulation of phagocytosis; positive regulation of cell proliferation