APC-Linked Polyclonal Antibody to Epithelial Cell Adhesion Molecule (EPCAM) | MyBioSource MBS2053508 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

APC-Linked Polyclonal Antibody to Epithelial Cell Adhesion Molecule (EPCAM)

catalog :

MBS2053508

quantity :

0.1 mg

price :

360 USD

clonality :

polyclonal

host :

rabbit

conjugate :

APC

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Figure. Western Blot; Sample: Recombinant MUC2, Porcine.

product information

catalog number :

MBS2053508

products type :

Antibody

products full name :

APC-Linked Polyclonal Antibody to Epithelial Cell Adhesion Molecule (EPCAM)

products short name :

[Epithelial Cell Adhesion Molecule (EPCAM)]

products name syn :

[CD326; TACSTD1; EGP; KSA; M4S1; MIC18; TROP1; HEGP2; ESA; Epithelial glycoprotein; Adenocarcinoma-associated antigen; Tumor Associated Calcium Signal Transducer 1]

other names :

[epithelial cell adhesion molecule; Epithelial cell adhesion molecule; epithelial cell adhesion molecule; epithelial cell adhesion molecule; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein; EGP; Epithelial glycoprotein 314; EGP314; hEGP314; KS 1/4 antigen; KSA; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1; CD_antigen: CD326]

products gene name :

[EPCAM]

other gene names :

[EPCAM; EPCAM; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1; Ep-CAM; EGP; EGP314; hEGP314]

clonality :

Polyclonal

host :

Rabbit

purity :

Antigen-specific Affinity Chromatography.

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

concentration :

0.3 mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

WB; IHC; ICC; IP.

app notes :

Western blotting: 0.5-2 u/mL;1:150-600. Immunohistochemistry: 5-20 ug/mL;1:15-60. Immunocytochemistry: 5-20 ug/mL;1:15-60. Optimal working dilutions must be determined by end user

image1 heading :

Western Blot (WB)

other info1 :

Organism Species: Bos taurus; Bovine (Cattle). Source: Antibody labeling. Label: APC. Traits: Liquid. Immunogen: Recombinant EPCAM (Gln25~Gln265+(LEHHHHHH)expressed in E.coli.

other info2 :

Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2028334

ncbi gi num :

218505670

ncbi acc num :

NP_002345.2

ncbi gb acc num :

NM_002354.2

uniprot acc num :

P16422

ncbi summary :

This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]

uniprot summary :

EPCAM: a single-pass type I membrane protein of the EPCAM family. May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas including pancreatic carcinoma. May be a marker of cancer stem cells. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 2p21. Cellular Component: apical plasma membrane; basolateral plasma membrane; integral to plasma membrane; lateral plasma membrane; plasma membrane; tight junction. Molecular Function: protein binding; protein complex binding. Biological Process: positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; stem cell differentiation. Disease: Colorectal Cancer, Hereditary Nonpolyposis, Type 8; Diarrhea 5, With Tufting Enteropathy, Congenital

size1 :

0.1 mg

price1 :

360 USD

size2 :

0.2 mg

price2 :

560

size3 :

1 mg

price3 :

1340

more info or order :

MyBioSource product webpage