protein

QKI, 1-341aa, Human, His tag, E Coli

MBS205334

0.05 mg

310 USD

Recombinant Protein

QKI, 1-341aa, Human, His tag, E Coli

QKI

Protein quaking isoform HQK-5; Hqk; hqkI; QK; QK1; QK3

protein quaking isoform 1; Protein quaking; protein quaking; RNA binding protein HQK; homolog of mouse quaking QKI (KH domain RNA binding protein); quaking homolog, KH domain RNA binding; QKI, KH domain containing, RNA binding

QKI

QKI; QKI; QK; Hqk; QK1; QK3; hqkI; HKQ; Hqk; HqkI

QKI_HUMAN

341

MGSSHHHHHH SSGLVPRGSH MGSMVGEMET KEKPKPTPDY LMQLMNDKKL MSSLPNFCGI FNHLERLLDE EISRVRKDMY NDTLNGSTEK RSAELPDAVG PIVQLQEKLY VPVKEYPDFN FVGRILGPRG LTAKQLEAET GCKIMVRGKG SMRDKKKEEQ NRGKPNWEHL NEDLHVLITV EDAQNRAEIK LKRAVEEVKK LLVPAAEGED SLKKMQLMEL AILNGTYRDA NIKSPALAFS LAATAQAAPR IITGPAPVLP PAALRTPTPA GPTIMPLIRQ IQTAVMPNGT PHPTAAIVPP GPEAGLIYTP YEYPYTLAPA TSILEYPIEP SGVLGAVATK VRRHDMRVHP YQRIVTADRA ATGN

> 85% by SDS - PAGE

Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT

0.25mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Epigenomics

Protein quaking isoform HQK-5, also known as QKI, is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. It is involved in myelinization and oligodendrocyte differentiation, and it may play a role in schizophrenia. Defects or deletions in the QKI are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Recombinant human QKI protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Hardy R J., et al. (1996) J Neurosci. 16: 7941-7949. Ebersole T A., et al. (1996) Nat Genet. 12: 260-265.

45827706

NP_006766

NM_006775.2

40.1 kDa (364aa) confirmed by MALDI-TOF

Diurnally Regulated Genes With Circadian Orthologs Pathway (198813)

The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

QKI: RNA-binding protein that plays a central role in myelinization. Binds to the 5 -NACUAAY-N(1,20)-UAAY-3 RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor. 6 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 6q26. Cellular Component: cytoplasm; nucleus. Molecular Function: mRNA binding; protein binding; SH3 domain binding. Biological Process: myelination; regulation of translation; muscle cell differentiation; mRNA transport; RNA splicing; long-chain fatty acid biosynthetic process; vasculogenesis; mRNA processing; spermatid development

0.05 mg

310 USD

0.25 mg

720