catalog number :
MBS205326
products type :
Recombinant Protein
products full name :
CEACAM7, 36-242aa, Human, His tag, E Coli
products short name :
CEACAM7
products name syn :
Carcinoembryonic antigen-related cell adhesion molecule 7; CEA; Carcinoembryonic antigen related cell adhesion molecule 7
other names :
Carcinoembryonic antigen-related cell adhesion molecule 7; Carcinoembryonic antigen-related cell adhesion molecule 7; carcinoembryonic antigen-related cell adhesion molecule 7; carcinoembryonic antigen CGM2; carcinoembryonic antigen gene family member 2; carcinoembryonic antigen-related cell adhesion molecule 7; Carcinoembryonic antigen CGM2
products gene name :
CEACAM7
other gene names :
CEACAM7; CEACAM7; CEA; CGM2; CGM2
uniprot entry name :
CEAM7_HUMAN
sequence :
MGSSHHHHHH SSGLVPRGSH MGSTNIDVVP FNVAEGKEVL LVVHNESQNL YGYNWYKGER VHANYRIIGY VKNISQENAP GPAHNGRETI YPNGTLLIQN VTHNDAGIYT LHVIKENLVN EEVTRQFYVF SEPPKPSITS NNFNPVENKD IVVLTCQPET QNTTYLWWVN NQSLLVSPRL LLSTDNRTLV LLSATKNDIG PYECEIQNPV GASRSDPVTL NVRYESVQAS
purity :
> 85% by SDS - PAGE
form :
Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol.
concentration :
0.25 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Cancer
products description :
CEACAM7 belongs to the immunoglobulin superfamily This protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CEACAM7 is strongly down-regulated in colonic adenocarcinomas. Recombinant human CEACAM7 fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Thompson J, Seitz M, et al. (1997). Cancer Res. 57(9):1776-84. Kinugasa T, Kuroki M, et al. (1998). Int J Cancer. 76(1):148-53.
ncbi mol weight :
25.7kDa (230aa)
ncbi summary :
This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
uniprot summary :
CEACAM7: Belongs to the immunoglobulin superfamily. CEA family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Immunoglobulin superfamily; Membrane protein, GPI anchor; Membrane protein, integral. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: integral to membrane; plasma membrane