antibody

HRP-Linked Polyclonal Antibody to Lysozyme (LZM)

MBS2052328

0.1 mg

285 USD

polyclonal

rabbit

HRP

western blot, immunohistochemistry, immunocytochemistry

Antibody

HRP-Linked Polyclonal Antibody to Lysozyme (LZM)

[Lysozyme (LZM)]

[LYZ; Renal Amyloidosis; N-Acetylmuramide Glycanhydrolase; Muramidase; 1, 4-beta-N-acetylmuramidase C]

[lysozyme (EC 3.2.1.17); Lysozyme C; lysozyme C; lysozyme; 1,4-beta-N-acetylmuramidase C]

[LZM]

[LYZ; LYZ; LZM; LYZF1; LZM]

Polyclonal

Rabbit

Antigen-specific Affinity Chromatography.

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

0.65 mg/ml

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

WB; IHC; ICC.

Western blotting: 0.5-2 ug/mL;1:450-1800. Immunohistochemistry: 5-20 ug/mL;1:45-180. Immunocytochemistry: 5-20 ug/mL;1:45-180. Optimal working dilutions must be determined by end user.

Organism Species: Chicken (Gallus). Source: Antibody labeling. Label: HRP. Traits: Liquid. Immunogen: Recombinant MYO (Met1~Gly154) expressed in E.coli.

Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2026854

307142

AAA59536.1

16,537 Da

Amyloid Fiber Formation Pathway (1269169); C-MYB Transcription Factor Network Pathway (138073); Metabolism Of Proteins Pathway (1268677); Salivary Secretion Pathway (153376); Salivary Secretion Pathway (153352)

This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]

LYZ: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents. Defects in LYZ are a cause of amyloidosis type 8 (AMYL8); also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. Belongs to the glycosyl hydrolase 22 family. Protein type: EC 3.2.1.17; Endoplasmic reticulum; Hydrolase; Secreted; Secreted, signal peptide; Vesicle. Chromosomal Location of Human Ortholog: 12q15. Cellular Component: extracellular region; extracellular space. Molecular Function: identical protein binding; lysozyme activity. Biological Process: cell wall catabolic process; cellular protein metabolic process; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; inflammatory response; retinal homeostasis. Disease: Amyloidosis, Familial Visceral

0.1 mg

285 USD

0.2 mg

445

1 mg

1060