catalog number :
MBS2052171
products full name :
APC/CY7-Linked Polyclonal Antibody to Interleukin 31 (IL31)
products short name :
[Interleukin 31 (IL31)]
other names :
[interleukin-31; Interleukin-31; interleukin-31; interleukin 31]
products gene name :
[IL31]
other gene names :
[IL31; IL31; IL-31; IL-31]
reactivity :
Mus musculus (Mouse)
purity :
Antigen-specific Affinity Chromatography.
form :
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
WB; IHC; ICC; IF.
app notes :
Western blotting: 0.5-2 Ug/mL.
Immunohistochemistry: 5-20 Ug/mL.
Immunocytochemistry: 5-20 Ug/mL.
Optimal working dilutions must be determined by end user
other info1 :
. Source: Antibody labeling. Immunogen: Recombinant IL31 (Ser28~Glu154) expressed in E.coli.
other info2 :
Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2028590
ncbi acc num :
NP_001014358.1
ncbi gb acc num :
NM_001014336.1
ncbi summary :
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]
uniprot summary :
IL31: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity. Protein type: Cytokine; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 12q24.31. Cellular Component: extracellular region; extracellular space