protein

AICDA, 1-198aa, Human, His tag, E Coli

MBS205181

0.1 mg

310 USD

Recombinant Protein

AICDA, 1-198aa, Human, His tag, E Coli

AICDA

Activation-induced cytidine deaminase; AID; ARP2; CDA2; HIGM2

single-stranded DNA cytosine deaminase; Single-stranded DNA cytosine deaminase; single-stranded DNA cytosine deaminase; cytidine aminohydrolase; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos; activation-induced cytidine deaminase; Activation-induced cytidine deaminase; Cytidine aminohydrolase

AICDA

AICDA; AICDA; AID; ARP2; CDA2; HIGM2; HEL-S-284; AID

AICDA_HUMAN

198

MGSSHHHHHH SSGLVPRGSH MDSLLMNRRK FLYQFKNVRW AKGRRETYLC YVVKRRDSAT SFSLDFGYLR NKNGCHVELL FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG NPNLSLRIFT ARLYFCEDRK AEPEGLRRLH RAGVQIAIMT FKDYFYCWNT FVENHERTFK AWEGLHENSV RLSRQLRRIL LPLYEVDDLR DAFRTLGL

> 85% by SDS - PAGE

Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

0.5 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Epigenomics

AICDA, also known as AID, is involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. This protein is required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. It may also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Recombinant human AICDA protein, fused to His-tag at N-terminus, was expressed in E.coli.

Guo J.u., et al. (2010) Cell. 145:423-434. Noguchi E., et al. (2001) J. Allergy Clin. 108:382-386

10190700

NP_065712

NM_020661.2

26.1kDa (218aa)

IL4-mediated Signaling Events Pathway (137933); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670); Primary Immunodeficiency Pathway (83125); Primary Immunodeficiency Pathway (537)

This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]

AID: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family. Protein type: EC 3.5.4.38; Hydrolase. Chromosomal Location of Human Ortholog: 12p13. Cellular Component: cytoplasm; exosome (RNase complex); nucleus. Molecular Function: protein binding; zinc ion binding; ubiquitin protein ligase binding; cytidine deaminase activity. Biological Process: somatic diversification of immunoglobulins; B cell differentiation; somatic hypermutation of immunoglobulin genes; isotype switching; cytidine deamination; mRNA processing. Disease: Immunodeficiency With Hyper-igm, Type 2

0.1 mg

310 USD

0.5 mg

720