APC-Linked Polyclonal Antibody to Low Density Lipoprotein Receptor (LDLR) | MyBioSource MBS2050414 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

APC-Linked Polyclonal Antibody to Low Density Lipoprotein Receptor (LDLR)

catalog :

MBS2050414

quantity :

0.1 mg

price :

325 USD

clonality :

polyclonal

host :

rabbit

conjugate :

APC

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2050414

products type :

Antibody

products full name :

APC-Linked Polyclonal Antibody to Low Density Lipoprotein Receptor (LDLR)

products short name :

[Low Density Lipoprotein Receptor (LDLR)]

products name syn :

[FH; FHC; Familial Hypercholesterolemia]

other names :

[low density lipoprotein receptor; Low-density lipoprotein receptor; low-density lipoprotein receptor; low density lipoprotein receptor]

products gene name :

[LDLR]

other gene names :

[LDLR; LDLR; FH; FHC; LDLCQ2; LDL receptor]

clonality :

Polyclonal

host :

Rabbit

purity :

Antigen-specific Affinity Chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

concentration :

0.26 mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP).

app notes :

Western blotting: 0.5-2 ug/mL;1:130-520. Immunohistochemistry: 5-20 ug/mL;1:13-52. Immunocytochemistry: 5-20 ug/mL;1:13-52. Optimal working dilutions must be determined by end user.

other info1 :

Organism Species: Rattus norvegicus (Rat). Source: Antibody labeling. Label: APC. Traits: Liquid. Immunogen: Recombinant LDLR (Ile335~Ile588) expressed in E.coli.

other info2 :

Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2027252

ncbi gi num :

307121

ncbi acc num :

AAA56833.1

ncbi pathways :

Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Chylomicron-mediated Lipid Transport Pathway (106157); DNA Damage Response (only ATM Dependent) Pathway (198827); Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Hepatitis C Pathway (173973); Hepatitis C Pathway (173907)

ncbi summary :

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]

uniprot summary :

LDLR: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR are the cause of familial hypercholesterolemia (FH); a common autosomal semi- dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis). Belongs to the LDLR family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Cell surface; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 19p13.2. Cellular Component: apical part of cell; basolateral plasma membrane; cell surface; coated pit; early endosome; endosome membrane; external side of plasma membrane; Golgi apparatus; integral to plasma membrane; late endosome; lysosome; membrane; plasma membrane; receptor complex. Molecular Function: clathrin heavy chain binding; glycoprotein binding; identical protein binding; low-density lipoprotein binding; low-density lipoprotein receptor activity; protease binding; protein binding; very-low-density lipoprotein receptor activity. Biological Process: cholesterol absorption; cholesterol homeostasis; cholesterol transport; endocytosis; lipid metabolic process; phospholipid transport; receptor-mediated endocytosis. Disease: Hypercholesterolemia, Familial

size1 :

0.1 mg

price1 :

325 USD

size2 :

0.2 mg

price2 :

505

size3 :

1 mg

price3 :

1215

more info or order :

MyBioSource product webpage