product summary
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company name :
MyBioSource
product type :
protein
product name :
CD79B, 29-159aa, Human, His tag, E Coli
catalog :
MBS205026
quantity :
0.1 mg
price :
310 USD
more info or order :
product information
catalog number :
MBS205026
products type :
Recombinant Protein
products full name :
CD79B, 29-159aa, Human, His tag, E Coli
products short name :
CD79B
products name syn :
CD79b molecule; immunoglobulin-associated beta; AGM6; B29; IGB
other names :
B-cell antigen receptor complex-associated protein beta chain isoform 1; B-cell antigen receptor complex-associated protein beta chain; B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; CD79b antigen (immunoglobulin-associated beta); Ig-beta; immunoglobulin-associated B29 protein; CD79b molecule, immunoglobulin-associated beta; B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein; CD_antigen: CD79b
products gene name :
CD79B
other gene names :
CD79B; CD79B; B29; IGB; AGM6; B29; IGB
uniprot entry name :
CD79B_HUMAN
sequence length :
229
sequence :
MGSSHHHHHH SSGLVPRGSH MGSMARSEDR YRNPKGSACS RIWQSPRFIA RKRGFTVKMH CYMNSASGNV SWLWKQEMDE NPQQLKLEKG RMEESQNESL ATLTIQGIRF EDNGIYFCQQ KCNNTSEVYQ GCGTELRVMG FSTLAQLKQR NTLKD
purity :
> 90% by SDS - PAGE
form :
Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2M uREA, 10% glycerol
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human. Tag: His-tag
other info2 :
Expression System: E Coli
products categories :
Immunology
products description :
CD79B, also known as Igb and B29, is a 36 kDa transmembrane glycoprotein in the immunoglobulin superfamily. Heterodimers of CD79A and CD79B associate with a membrane bound immunoglobulin on the B cell surface to form the B cell antigen receptor complex(BCR). CD79A and CD79B are required for BCR-mediated signaling and consequently for the development and activation of B lineage cells. Recombinant human CD79B protein, fused to His-tag at N-terminus, was expressed in E.coli.
products references :
Naylor,T.L., et al. (2011) Cancer Res. 71 (7), 2643-2653
ncbi gi num :
11038674
ncbi acc num :
NP_000617
ncbi gb acc num :
NM_000626.2
ncbi mol weight :
17.7 kDa (155aa)
ncbi pathways :
Adaptive Immune System Pathway (366160); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (576249); B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); BCR Signaling Pathway (138058); Immune System Pathway (106386); Signaling By The B Cell Receptor (BCR) Pathway (576248)
ncbi summary :
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
uniprot summary :
Ig-beta: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 17q23. Cellular Component: nucleoplasm; Golgi apparatus; integral to plasma membrane; cytoplasm; plasma membrane; B cell receptor complex; external side of plasma membrane. Molecular Function: transmembrane receptor activity. Biological Process: B cell receptor signaling pathway; immune response; signal transduction. Disease: Agammaglobulinemia 6, Autosomal Recessive
size1 :
0.1 mg
price1 :
310 USD
size2 :
0.5 mg
price2 :
720
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
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