protein

XPA, 1-273aa, Human, His tag, E Coli (Denatured)

MBS205019

0.1 mg

310 USD

Recombinant Protein

XPA, 1-273aa, Human, His tag, E Coli (Denatured)

[XPA]

[DNA repair protein complementing XP-A cells; XP1; XPAC]

[DNA repair protein complementing XP-A cells isoform 1; DNA repair protein complementing XP-A cells; DNA repair protein complementing XP-A cells; XPA, DNA damage recognition and repair factor; Xeroderma pigmentosum group A-complementing protein]

[XPA]

[XPA; XPA; XP1; XPAC; XPAC]

E Coli

273

MGSSHHHHHH SSGLVPRGSH MGSMAAADGA LPEAAALEQP AELPASVRAS IERKRQRALM LRQARLAARP YSATAAAATG GMANVKAAPK IIDTGGGFIL EEEEEEEQKI GKVVHQPGPV MEFDYVICEE CGKEFMDSYL MNHFDLPTCD NCRDADDKHK LITKTEAKQE YLLKDCDLEK REPPLKFIVK KNPHHSQWGD MKLYLKLQIV KRSLEVWGSQ EALEEAKEVR QENREKMKQK KFDKKVKELR RAVRSSVWKR ETIVHQHEYG PEENLEDDMY RKTCTMCGHE LTYEKM

> 85% by SDS-PAGE

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol

1 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

SDS-Page

Antigen Species: Human. Tag Information: His-tag

Epigenomics

XPA, also known as DNA repair protein complementing XP-A cells, belong to the XPA family. This protein is involved in DNA excision repair. It Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Defects in XPA are a cause of xeroderma pigmentosum complementation group A (XP-A), which is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Recombinant human XPA protein, fused to His-tag at N-terminus, was expressed in E Coli.

Pan Y.R., et al. (2009) Cell Cycle 8:655-664; James, et al. (2005) Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders.;

4507937

NP_000371

NM_000380.3

P23025

33.8 kDa (296aa)

DNA Repair Pathway (1270350); Dual Incision In GG-NER Pathway (1309115); Dual Incision In TC-NER Pathway (1309119); Formation Of Incision Complex In GG-NER Pathway (1309114); Formation Of TC-NER Pre-Incision Complex Pathway (1309118); Global Genome Nucleotide Excision Repair (GG-NER) Pathway (1309112); Nucleotide Excision Repair Pathway (1309111); Nucleotide Excision Repair Pathway (83044); Nucleotide Excision Repair Pathway (452); Platinum Drug Resistance Pathway (1404797)

This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017]

Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.

0.1 mg

310 USD

0.5 mg

720