protein

BPIFA1, 20-256aa, Human, His tag, E Coli

MBS204992

0.1 mg

310 USD

Recombinant Protein

BPIFA1, 20-256aa, Human, His tag, E Coli

BPIFA1

BPI fold-containing family A; member 1; bA49G10.5; LPLuNC3; LuNX; NASG; PLuNC; SPuRT

BPI fold-containing family A member 1; BPI fold-containing family A member 1; BPI fold-containing family A member 1; ligand-binding protein RYA3; lung-specific protein X; nasopharyngeal carcinoma-related protein; palate lung and nasal epithelium clone protein; palate, lung and nasal epithelium associated; protein Plunc; secretory protein in upper respiratory tracts; short PLUNC1; tracheal epithelium enriched protein; tracheal epithelium-enriched protein; von Ebner protein Hl; BPI fold containing family A, member 1; Lung-specific protein X; Nasopharyngeal carcinoma-related protein; Palate lung and nasal epithelium clone protein; Secretory protein in upper respiratory tracts; Short PLUNC1; SPLUNC1; Tracheal epithelium-enriched protein; Von Ebner protein Hl

BPIFA1

BPIFA1; BPIFA1; LUNX; NASG; PLUNC; SPURT; SPLUNC1; bA49G10.5; LUNX; NASG; PLUNC; SPLUNC1; SPURT; SPLUNC1

BPIA1_HUMAN

256

MGSSHHHHHH SSGLVPRGSH MGSQFGGLPV PLDQTLPLNV NPALPLSPTG LAGSLTNALS NGLLSGGLLG ILENLPLLDI LKPGGGTSGG LLGGLLGKVT SVIPGLNNII DIKVTDPQLL ELGLVQSPDG HRLYVTIPLG IKLQVNTPLV GASLLRLAVK LDITAEILAV RDKQERIHLV LGDCTHSPGS LQISLLDGLG PLPIQGLLDS LTGILNKVLP ELVQGNVCPL VNEVLRGLDI TLVHDIVNML IHGLQFVIKV

> 90% by SDS - PAGE

Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 30% glycerol

1 mg/ml (determined by BCA assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Immunology

BPIFA1, also known as PLuNC, belongs to the short subfamily of PLuNC family proteins and have homology only to the Nterminal domains of BPI. It is a secreted protein that is expressed in the secretory ducts and submucosal glands of tracheobronchial tissues. BPIFA1 binds to lipopolysaccharide (LPS) in nasal lavage fluid (NLF) which points to its role in the inflammatory response of the upper airways after exposure to irritants. Decreased levels of BPIFA1 occur in the NLF of smokers and people who have been exposed to reactive epoxy chemicals, indicating that long-term exposure to airway irritants impairs the production of BPIFA1 in the upper respiratory tract. Recombinant human BPIFA1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Ghafouri B., et al. (2004) Biochem Biophys Acta. 1699:57-63. Bingle C D., et al. (2002) Hum Mol Genet. 11: 937-943.

7706119

NP_057667

NM_016583.3

27.1 kDa (260aa), confirmed by MALDI-TOF

This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2014]

PLUNC: May be involved in the airway inflammatory response after exposure to irritants. May be associated with tumor progression. May play a role in innate immune responses of the upper airways. Belongs to the BPI/LBP/Plunc superfamily. Plunc family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 20q11.2. Cellular Component: extracellular space; extracellular region. Molecular Function: lipid binding. Biological Process: antibacterial humoral response; innate immune response; regulation of liquid surface tension; multicellular organismal water homeostasis

0.1 mg

310 USD

0.5 mg

720