protein

TAF15, 148-406aa, Human, His tag, E Coli

MBS204867

0.1 mg

375 USD

Recombinant Protein

TAF15, 148-406aa, Human, His tag, E Coli

TAF15

TATA-binding protein-associated factor 2N isoform 1; Npl3; RBP56; TAF2N; TAFII68

TATA-binding protein-associated factor 2N isoform 1; TATA-binding protein-associated factor 2N; TATA-binding protein-associated factor 2N; RBP56/CSMF fusion; TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56); TATA box-binding protein-associated factor 2N (RNA-binding protein 56); TBP-associated factor 15; TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa; 68 kDa TATA-binding protein-associated factor; TAF(II)68; TAFII68; RNA-binding protein 56

TAF15

TAF15; TAF15; Npl3; RBP56; TAF2N; TAFII68; RBP56; TAF2N; TAF(II)68; TAFII68

RBP56_HUMAN

592

MGSSHHHHHH SSGLVPRGSH MGSSYHSQRE NYSHHTQDDR RDVSRYGEDN RGYGGSQGGG RGRGGYDKDG RGPMTGSSGG DRGGFKNFGG HRDYGPRTDA DSESDNSDNN TIFVQGLGEG VSTDQVGEFF KQIGIIKTNK KTGKPMINLY TDKDTGKPKG EATVSFDDPP SAKAAIDWFD GKEFHGNIIK VSFATRRPEF MRGGGSGGGR RGRGGYRGRG GFQGRGGDPK SGDWVCPNPS CGNMNFARRN SCNQCNEPRP EDSRPSGGDF RGRGYGGERG YR

> 90% by SDS - PAGE

Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol, 1mM DTT

0.25 mg/ml (determined by Bradford assay)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

SDS-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Epigenomics (Transcription & Translation)

TAF15 is a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Recombinant human TAF15 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Martini A, La Starza R, et al. (2002). Cancer Res. 62(19):5408-12.

21327701

NP_631961

NM_139215.2

30kDa (282aa), confirmed by MALDI-TOF

Basal Transcription Factors Pathway (83038); Basal Transcription Factors Pathway (443); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

TAF15: RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3. Belongs to the RRM TET family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Translation; RNA-binding; Oncoprotein. Chromosomal Location of Human Ortholog: 17q11.1-q11.2. Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus. Molecular Function: protein binding; DNA binding; zinc ion binding; nucleotide binding. Biological Process: positive regulation of transcription, DNA-dependent. Disease: Chondrosarcoma, Extraskeletal Myxoid

0.1 mg

375 USD

0.5 mg

925