catalog number :
MBS204731
products type :
Recombinant Protein
products full name :
PINK1, 156-507aa, Human, E Coli
products short name :
PINK1
products name syn :
Serine/threonine-protein kinase PINK1; mitochondrial; BRPK; FLJ27236; PARK6
other names :
serine/threonine-protein kinase PINK1, mitochondrial; Serine/threonine-protein kinase PINK1, mitochondrial; serine/threonine-protein kinase PINK1, mitochondrial; PTEN-induced putative kinase protein 1; protein kinase BRPK; PTEN induced putative kinase 1; BRPK; PTEN-induced putative kinase protein 1
products gene name :
PINK1
other gene names :
PINK1; PINK1; BRPK; PARK6
uniprot entry name :
PINK1_HUMAN
sequence :
MYLIGQSIGK GCSAAVYEAT MPTLPQNLEV TKSTGLLPGR GPGTSAPGEG QERAPGAPAF PLAIKMMWNI SAGSSSEAIL NTMSQELVPA SRVALAGEYG AVTYRKSKRG PKQLAPHPNI IRVLRAFTSS VPLLPGALVD YPDVLPSRLH PEGLGHGRTL FLVMKNYPCT LRQYLCVNTP SPRLAAMMLL QLLEGVDHLV QQGIAHRDLK SDNILVELDP DGCPWLVIAD FGCCLADESI GLQLPFSSWY VDRGGNGCLM APEVSTARPG PRAVIDYSKA DAWAVGAIAY EIFGLVNPFY GQGKAHLESR SYQEAQLPAL PESVPPDVRQ LVRALLQREA SKRPSARVAA NVL
purity :
> 90 % by SDS - PAGE
form :
Liquid. In 20mM Tris-HCl buffer (pH 8.0) 1M urea, 5% Glycerol.
concentration :
1 mg/ml (determined by Bradford assay)
storage stability :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
tested application :
SDS-PAGE
other info1 :
Antigen Species: Human
other info2 :
Expression System: E Coli
products categories :
Neuroscience
products description :
PINK1 is a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this protein cause one form of autosomal recessive early-onset Parkinson disease. Recombinant human PINK protein was expressed in E.coli and purified by using conventional chromatography techniques.
products references :
Valente EM., et al. (2004) Ann Neurol. 56(3):336-41. unoki M., et al. (2001) Oncogene. 20(33):4457-65.
ncbi gb acc num :
NM_032409.2
ncbi mol weight :
37.9 kDa (353aa)
ncbi pathways :
Parkinson's Disease Pathway 83098!!Parkinsons Disease Pathway 705377
ncbi summary :
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]